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Page 1
Structural Modeling Insights into Human VKORC1 Phenotypes.
Nutrients. 2015 Aug 14;7(8):6837-51. doi: 10.3390/nu7085313.
Nutrients. 2015.
PMID: 26287237
Free PMC article.
Review.
Warfarin and vitamin K compete for binding to Phe55 in human VKOR.
Czogalla KJ, Biswas A, Höning K, Hornung V, Liphardt K, Watzka M, Oldenburg J.
Czogalla KJ, et al.
Nat Struct Mol Biol. 2017 Jan;24(1):77-85. doi: 10.1038/nsmb.3338. Epub 2016 Dec 12.
Nat Struct Mol Biol. 2017.
PMID: 27941861
Item in Clipboard
VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites.
Czogalla KJ, Liphardt K, Höning K, Hornung V, Biswas A, Watzka M, Oldenburg J.
Czogalla KJ, et al.
Blood Adv. 2018 Mar 27;2(6):691-702. doi: 10.1182/bloodadvances.2017006775.
Blood Adv. 2018.
PMID: 29581108
Free PMC article.
Item in Clipboard
The Arg98Trp mutation in human VKORC1 causing VKCFD2 disrupts a di-arginine-based ER retention motif.
Czogalla KJ, Biswas A, Rost S, Watzka M, Oldenburg J.
Czogalla KJ, et al.
Blood. 2014 Aug 21;124(8):1354-62. doi: 10.1182/blood-2013-12-545988. Epub 2014 Jun 24.
Blood. 2014.
PMID: 24963046
Free article.
Item in Clipboard
Human VKORC1 mutations cause variable degrees of 4-hydroxycoumarin resistance and affect putative warfarin binding interfaces.
Czogalla KJ, Biswas A, Wendeln AC, Westhofen P, Müller CR, Watzka M, Oldenburg J.
Czogalla KJ, et al.
Blood. 2013 Oct 10;122(15):2743-50. doi: 10.1182/blood-2013-05-501692. Epub 2013 Aug 27.
Blood. 2013.
PMID: 23982176
Free article.
Item in Clipboard
Variants in FIX propeptide associated with vitamin K antagonist hypersensitivity: functional analysis and additional data confirming the common founder mutations.
Pezeshkpoor B, Czogalla KJ, Caspers M, Berkemeier AC, Liphardt K, Ghosh S, Kellner M, Ulrich S, Pavlova A, Oldenburg J.
Pezeshkpoor B, et al. Among authors: czogalla kj.
Ann Hematol. 2018 Jun;97(6):1061-1069. doi: 10.1007/s00277-018-3264-2. Epub 2018 Feb 15.
Ann Hematol. 2018.
PMID: 29450643
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Two enzymes catalyze vitamin K 2,3-epoxide reductase activity in mouse: VKORC1 is highly expressed in exocrine tissues while VKORC1L1 is highly expressed in brain.
Caspers M, Czogalla KJ, Liphardt K, Müller J, Westhofen P, Watzka M, Oldenburg J.
Caspers M, et al. Among authors: czogalla kj.
Thromb Res. 2015 May;135(5):977-83. doi: 10.1016/j.thromres.2015.01.025. Epub 2015 Jan 26.
Thromb Res. 2015.
PMID: 25747820
Free article.
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