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Hexokinases inhibit death receptor-dependent apoptosis on the mitochondria.
Lauterwasser J, Fimm-Todt F, Oelgeklaus A, Schreiner A, Funk K, Falquez-Medina H, Klesse R, Jahreis G, Zerbes RM, O'Neill K, van der Laan M, Luo X, Edlich F. Lauterwasser J, et al. Among authors: funk k. Proc Natl Acad Sci U S A. 2021 Aug 17;118(33):e2021175118. doi: 10.1073/pnas.2021175118. Proc Natl Acad Sci U S A. 2021. PMID: 34385311 Free PMC article.
Parkin promotes proteasomal degradation of misregulated BAX.
Cakir Z, Funk K, Lauterwasser J, Todt F, Zerbes RM, Oelgeklaus A, Tanaka A, van der Laan M, Edlich F. Cakir Z, et al. Among authors: funk k. J Cell Sci. 2017 Sep 1;130(17):2903-2913. doi: 10.1242/jcs.200162. Epub 2017 Jul 31. J Cell Sci. 2017. PMID: 28760928
Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes.
Andreu-Fernández V, Sancho M, Genovés A, Lucendo E, Todt F, Lauterwasser J, Funk K, Jahreis G, Pérez-Payá E, Mingarro I, Edlich F, Orzáez M. Andreu-Fernández V, et al. Among authors: funk k. Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):310-315. doi: 10.1073/pnas.1612322114. Epub 2016 Dec 27. Proc Natl Acad Sci U S A. 2017. PMID: 28028215 Free PMC article.
Mitochondrial BAX Determines the Predisposition to Apoptosis in Human AML.
Reichenbach F, Wiedenmann C, Schalk E, Becker D, Funk K, Scholz-Kreisel P, Todt F, Wolleschak D, Döhner K, Marquardt JU, Heidel F, Edlich F. Reichenbach F, et al. Among authors: funk k. Clin Cancer Res. 2017 Aug 15;23(16):4805-4816. doi: 10.1158/1078-0432.CCR-16-1941. Epub 2017 Apr 18. Clin Cancer Res. 2017. PMID: 28420723