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A novel binding pocket in the D2 domain of protein tyrosine phosphatase mu (PTPmu) guides AI screen to identify small molecules that modulate tumour cell adhesion, growth and migration.
Molyneaux K, Laggner C, Brady-Kalnay SM. Molyneaux K, et al. J Cell Mol Med. 2023 Nov;27(22):3553-3564. doi: 10.1111/jcmm.17973. Epub 2023 Oct 20. J Cell Mol Med. 2023. PMID: 37860940 Free PMC article.
Seventy-five of the best-scoring and chemically diverse computational hits predicted to interact with the D2 binding pocket were screened for effects on tumour cell motility and growth in 3D culture as well as in a direct assay for PTPmu-dependent adhesion. We ident …
Seventy-five of the best-scoring and chemically diverse computational hits predicted to interact with the D2 binding pocket were screened fo …
Site-specific acetyl-mimetic modification of cardiac troponin I modulates myofilament relaxation and calcium sensitivity.
Lin YH, Schmidt W, Fritz KS, Jeong MY, Cammarato A, Foster DB, Biesiadecki BJ, McKinsey TA, Woulfe KC. Lin YH, et al. J Mol Cell Cardiol. 2020 Feb;139:135-147. doi: 10.1016/j.yjmcc.2020.01.007. Epub 2020 Jan 22. J Mol Cell Cardiol. 2020. PMID: 31981571 Free PMC article.
METHODS: To determine if pseudo-acetylation of cTnI at 132 modulates thin filament regulation of the acto-myosin interaction, we reconstituted thin filaments containing WT or K132Q (to mimic acetylation) cTnI and assessed in vitro motility. To test if mimicking acetylation …
METHODS: To determine if pseudo-acetylation of cTnI at 132 modulates thin filament regulation of the acto-myosin interaction, we reconstitut …
A single-headed fission yeast myosin V transports actin in a tropomyosin-dependent manner.
Tang Q, Billington N, Krementsova EB, Bookwalter CS, Lord M, Trybus KM. Tang Q, et al. J Cell Biol. 2016 Jul 18;214(2):167-79. doi: 10.1083/jcb.201511102. Epub 2016 Jul 11. J Cell Biol. 2016. PMID: 27432898 Free PMC article.
When Myo51-Rng8/9 was bound to actin-tropomyosin, two attachment sites were observed: the typical ATP-dependent motor domain attachment and a novel ATP-independent binding of the tail mediated by Rng8/9. A modified motility assay showed that this additional binding site an …
When Myo51-Rng8/9 was bound to actin-tropomyosin, two attachment sites were observed: the typical ATP-dependent motor domain attachment and …
Odontoblast cell death induces NLRP3 inflammasome-dependent sterile inflammation and regulates dental pulp cell migration, proliferation and differentiation.
Al Natour B, Lundy FT, Moynah PN, About I, Jeanneau C, Irwin CR, Domberoski Y, El Karim IA. Al Natour B, et al. Int Endod J. 2021 Jun;54(6):941-950. doi: 10.1111/iej.13483. Epub 2021 Feb 25. Int Endod J. 2021. PMID: 33503274
METHODS: Odontoblast-like cells were subjected to freezing-thawing cycles to produce odontoblast necrotic cell lysate (ONCL). DPCs were treated with ONCL to assess proliferation and migration. THP-1 differentiated macrophages stimulated with ONCL and live cell imagi …
METHODS: Odontoblast-like cells were subjected to freezing-thawing cycles to produce odontoblast necrotic cell lysate (ONCL). DPCs we …
Executive summary: A Quick Reference Guide for Managing Fecal Incontinence (FI).
Willson MM, Angyus M, Beals D, Callan L, Francis K, Kingan MJ, Porras OK. Willson MM, et al. J Wound Ostomy Continence Nurs. 2014 Jan-Feb;41(1):61-9. doi: 10.1097/WON.0000000000000004. J Wound Ostomy Continence Nurs. 2014. PMID: 24378693
The appendices provide additional information about predisposing factors for FI, assessment tools, medications and foods that affect gastric or colonic motility, and examples of FI management systems/collectors. The complete quick reference guide is available in the Member …
The appendices provide additional information about predisposing factors for FI, assessment tools, medications and foods that affect gastric …
Reconstitution of the core of the malaria parasite glideosome with recombinant Plasmodium class XIV myosin A and Plasmodium actin.
Bookwalter CS, Tay CL, McCrorie R, Previs MJ, Lu H, Krementsova EB, Fagnant PM, Baum J, Trybus KM. Bookwalter CS, et al. J Biol Chem. 2017 Nov 24;292(47):19290-19303. doi: 10.1074/jbc.M117.813972. Epub 2017 Oct 4. J Biol Chem. 2017. PMID: 28978649 Free PMC article.
Parasite motility is necessary for host-cell invasion and virulence, but studying its molecular basis has been hampered by unavailability of sufficient amounts of PfMyoA. ...Neither the presence of calcium nor deletion of the MTIP N-terminal extension changed the sp …
Parasite motility is necessary for host-cell invasion and virulence, but studying its molecular basis has been hampered by una …
Opposing Actions of AKT (Protein Kinase B) Isoforms in Vascular Smooth Muscle Injury and Therapeutic Response.
Jin Y, Xie Y, Ostriker AC, Zhang X, Liu R, Lee MY, Leslie KL, Tang W, Du J, Lee SH, Wang Y, Sessa WC, Hwa J, Yu J, Martin KA. Jin Y, et al. Arterioscler Thromb Vasc Biol. 2017 Dec;37(12):2311-2321. doi: 10.1161/ATVBAHA.117.310053. Epub 2017 Oct 12. Arterioscler Thromb Vasc Biol. 2017. PMID: 29025710 Free PMC article.
We have shown that rapamycin promotes vascular smooth muscle cell differentiation in an AKT2-dependent manner in vitro. Here, we investigate the roles of AKT (protein kinase B) isoforms in intimal hyperplasia. ...We identified opposing roles for AKT1 and AKT2 isoforms in s …
We have shown that rapamycin promotes vascular smooth muscle cell differentiation in an AKT2-dependent manner in vitro. Here, we inve …
A Toxoplasma gondii class XIV myosin, expressed in Sf9 cells with a parasite co-chaperone, requires two light chains for fast motility.
Bookwalter CS, Kelsen A, Leung JM, Ward GE, Trybus KM. Bookwalter CS, et al. J Biol Chem. 2014 Oct 31;289(44):30832-30841. doi: 10.1074/jbc.M114.572453. Epub 2014 Sep 17. J Biol Chem. 2014. PMID: 25231988 Free PMC article.
Many diverse myosin classes can be expressed using the baculovirus/Sf9 insect cell expression system, whereas others have been recalcitrant. We hypothesized that most myosins utilize Sf9 cell chaperones, but others require an organism-specific co-chaperone. ...Purif …
Many diverse myosin classes can be expressed using the baculovirus/Sf9 insect cell expression system, whereas others have been recalc …
IL-10-conditioned dendritic cells, decommissioned for recruitment of adaptive immunity, elicit innate inflammatory gene products in response to danger signals.
Nolan KF, Strong V, Soler D, Fairchild PJ, Cobbold SP, Croxton R, Gonzalo JA, Rubio A, Wells M, Waldmann H. Nolan KF, et al. J Immunol. 2004 Feb 15;172(4):2201-9. doi: 10.4049/jimmunol.172.4.2201. J Immunol. 2004. PMID: 14764687 Free article.
Dendritic cells (DCs) are the professional APCs of the immune system, enabling T cells to perceive and respond appropriately to potentially dangerous microbes, while also being able to maintain T cell tolerance toward self. In part, such tolerance can be determined by IL-1 …
Dendritic cells (DCs) are the professional APCs of the immune system, enabling T cells to perceive and respond appropriately to potentially …