Opposing Actions of AKT (Protein Kinase B) Isoforms in Vascular Smooth Muscle Injury and Therapeutic Response.
Jin Y, Xie Y, Ostriker AC, Zhang X, Liu R, Lee MY, Leslie KL, Tang W, Du J, Lee SH, Wang Y, Sessa WC, Hwa J, Yu J, Martin KA.
Jin Y, et al.
Arterioscler Thromb Vasc Biol. 2017 Dec;37(12):2311-2321. doi: 10.1161/ATVBAHA.117.310053. Epub 2017 Oct 12.
Arterioscler Thromb Vasc Biol. 2017.
PMID: 29025710
Free PMC article.
We have shown that rapamycin promotes vascular smooth muscle cell differentiation in an AKT2-dependent manner in vitro. Here, we investigate the roles of AKT (protein kinase B) isoforms in intimal hyperplasia. ...We identified opposing roles for AKT1 and AKT2 isoforms in s …
We have shown that rapamycin promotes vascular smooth muscle cell differentiation in an AKT2-dependent manner in vitro. Here, we inve …