Abstract
A series of 9-(pyridin-2'-yl)-aminoacridines was prepared and analyzed for their ability to change the thermal denaturation temperature of genomic calf thymus DNA. Development of a QSAR equation indicated that electron withdrawing groups on the pyridine ring promoted the interaction with double stranded DNA.
MeSH terms
-
Aminoacridines / chemical synthesis
-
Aminoacridines / chemistry*
-
Amsacrine / chemistry
-
Animals
-
Antineoplastic Agents, Alkylating / chemical synthesis
-
Antineoplastic Agents, Alkylating / chemistry*
-
Cattle
-
DNA / chemistry*
-
Hot Temperature
-
Humans
-
Nucleic Acid Denaturation
-
Pyridines / chemical synthesis
-
Pyridines / chemistry*
-
Quantitative Structure-Activity Relationship
-
Quinacrine / chemistry
Substances
-
Aminoacridines
-
Antineoplastic Agents, Alkylating
-
Pyridines
-
Amsacrine
-
DNA
-
calf thymus DNA
-
Quinacrine