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Multitargeting the Action of 5-HT6 Serotonin Receptor Ligands by Additional Modulation of Kinases in the Search for a New Therapy for Alzheimer's Disease: Can It Work from a Molecular Point of View?
Czarnota-Łydka K, Kucwaj-Brysz K, Pyka P, Haberek W, Podlewska S, Handzlik J. Czarnota-Łydka K, et al. Among authors: kucwaj brysz k. Int J Mol Sci. 2022 Aug 7;23(15):8768. doi: 10.3390/ijms23158768. Int J Mol Sci. 2022. PMID: 35955902 Free PMC article. Review.
Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma.
Ali W, Garbo S, Kincses A, Nové M, Spengler G, Di Bello E, Honkisz-Orzechowska E, Karcz T, Szymańska E, Żesławska E, Starek M, Dąbrowska M, Nitek W, Kucwaj-Brysz K, Pyka P, Fioravanti R, Jacob C, Battistelli C, Zwergel C, Handzlik J. Ali W, et al. Among authors: kucwaj brysz k. Eur J Med Chem. 2022 Dec 5;243:114761. doi: 10.1016/j.ejmech.2022.114761. Epub 2022 Sep 19. Eur J Med Chem. 2022. PMID: 36179403
An exit beyond the pharmacophore model for 5-HT6R agents - a new strategy to gain dual 5-HT6/5-HT2A action for triazine derivatives with procognitive potential.
Kucwaj-Brysz K, Ali W, Kurczab R, Sudoł-Tałaj S, Wilczyńska-Zawal N, Jastrzębska-Więsek M, Satała G, Mordyl B, Żesławska E, Agnieszka-Olejarz-Maciej, Czarnota K, Latacz G, Partyka A, Wesołowska A, Nitek W, Handzlik J. Kucwaj-Brysz K, et al. Bioorg Chem. 2022 Apr;121:105695. doi: 10.1016/j.bioorg.2022.105695. Epub 2022 Feb 19. Bioorg Chem. 2022. PMID: 35228010
Hydrophobicity modulation via the substituents at positions 2 and 4 of 1,3,5-triazine to enhance therapeutic ability against Alzheimer's disease for potent serotonin 5-HT6R agents.
Sudoł-Tałaj S, Kucwaj-Brysz K, Podlewska S, Kurczab R, Satała G, Mordyl B, Głuch-Lutwin M, Wilczyńska-Zawal N, Jastrzębska-Więsek M, Czarnota-Łydka K, Kurowska K, Kubacka M, Żesławska E, Nitek W, Olejarz-Maciej A, Doroz-Płonka A, Partyka A, Latacz G, Wesołowska A, Handzlik J. Sudoł-Tałaj S, et al. Among authors: kucwaj brysz k. Eur J Med Chem. 2023 Nov 15;260:115756. doi: 10.1016/j.ejmech.2023.115756. Epub 2023 Aug 24. Eur J Med Chem. 2023. PMID: 37657272 Free article.
23 results