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Page 1
The impact of individual human cytochrome P450 enzymes on oxidative metabolism of anticancer drug lenvatinib.
Biomed Pharmacother. 2022 Jan;145:112391. doi: 10.1016/j.biopha.2021.112391. Epub 2021 Nov 27.
Biomed Pharmacother. 2022.
PMID: 34847475
Free article.
Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation.
Indra R, Pompach P, Martínek V, Takácsová P, Vavrová K, Heger Z, Adam V, Eckschlager T, Kopečková K, Arlt VM, Stiborová M.
Indra R, et al. Among authors: vavrova k.
Int J Mol Sci. 2019 Jul 10;20(14):3392. doi: 10.3390/ijms20143392.
Int J Mol Sci. 2019.
PMID: 31295928
Free PMC article.
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Cytochrome P450 and flavin-containing monooxygenase enzymes are responsible for differential oxidation of the anti-thyroid-cancer drug vandetanib by human and rat hepatic microsomal systems.
Indra R, Pompach P, Vavrová K, Jáklová K, Heger Z, Adam V, Eckschlager T, Kopečková K, Arlt VM, Stiborová M.
Indra R, et al. Among authors: vavrova k.
Environ Toxicol Pharmacol. 2020 Feb;74:103310. doi: 10.1016/j.etap.2019.103310. Epub 2019 Dec 3.
Environ Toxicol Pharmacol. 2020.
PMID: 31837525
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Identification of Enzymes Oxidizing the Tyrosine Kinase Inhibitor Cabozantinib: Cabozantinib Is Predominantly Oxidized by CYP3A4 and Its Oxidation Is Stimulated by cyt b5 Activity.
Indra R, Vavrová K, Pompach P, Heger Z, Hodek P.
Indra R, et al. Among authors: vavrova k.
Biomedicines. 2020 Nov 28;8(12):547. doi: 10.3390/biomedicines8120547.
Biomedicines. 2020.
PMID: 33260548
Free PMC article.
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