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Year Number of Results
2008 1
2012 1
2013 2
2014 3
2015 2
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2017 2
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2020 4
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2023 3
2024 1

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Page 1
Structure-Activity Relationship of Propargylamine-Based HDAC Inhibitors.
Wünsch M, Senger J, Schultheisz P, Schwarzbich S, Schmidtkunz K, Michalek C, Klaß M, Goskowitz S, Borchert P, Praetorius L, Sippl W, Jung M, Sewald N. Wünsch M, et al. Among authors: schmidtkunz k. ChemMedChem. 2017 Dec 19;12(24):2044-2053. doi: 10.1002/cmdc.201700550. Epub 2017 Nov 30. ChemMedChem. 2017. PMID: 29120081
A novel pan-selective bromodomain inhibitor for epigenetic drug design.
Warstat R, Pervaiz M, Regenass P, Amann M, Schmidtkunz K, Einsle O, Jung M, Breit B, Hügle M, Günther S. Warstat R, et al. Among authors: schmidtkunz k. Eur J Med Chem. 2023 Mar 5;249:115139. doi: 10.1016/j.ejmech.2023.115139. Epub 2023 Jan 25. Eur J Med Chem. 2023. PMID: 36736153
First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement.
Herp D, Ridinger J, Robaa D, Shinsky SA, Schmidtkunz K, Yesiloglu TZ, Bayer T, Steimbach RR, Herbst-Gervasoni CJ, Merz A, Romier C, Sehr P, Gunkel N, Miller AK, Christianson DW, Oehme I, Sippl W, Jung M. Herp D, et al. Among authors: schmidtkunz k. Chembiochem. 2022 Jul 19;23(14):e202200180. doi: 10.1002/cbic.202200180. Epub 2022 Jun 10. Chembiochem. 2022. PMID: 35608330 Free PMC article.
Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity.
Darwish S, Ghazy E, Heimburg T, Herp D, Zeyen P, Salem-Altintas R, Ridinger J, Robaa D, Schmidtkunz K, Erdmann F, Schmidt M, Romier C, Jung M, Oehme I, Sippl W. Darwish S, et al. Among authors: schmidtkunz k. Int J Mol Sci. 2022 Jul 7;23(14):7535. doi: 10.3390/ijms23147535. Int J Mol Sci. 2022. PMID: 35886887 Free PMC article.
Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors.
Vögerl K, Ong N, Senger J, Herp D, Schmidtkunz K, Marek M, Müller M, Bartel K, Shaik TB, Porter NJ, Robaa D, Christianson DW, Romier C, Sippl W, Jung M, Bracher F. Vögerl K, et al. Among authors: schmidtkunz k. J Med Chem. 2019 Feb 14;62(3):1138-1166. doi: 10.1021/acs.jmedchem.8b01090. Epub 2019 Feb 1. J Med Chem. 2019. PMID: 30645113 Free PMC article.
Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation.
Relitti N, Saraswati AP, Chemi G, Brindisi M, Brogi S, Herp D, Schmidtkunz K, Saccoccia F, Ruberti G, Ulivieri C, Vanni F, Sarno F, Altucci L, Lamponi S, Jung M, Gemma S, Butini S, Campiani G. Relitti N, et al. Among authors: schmidtkunz k. Eur J Med Chem. 2021 Feb 15;212:112998. doi: 10.1016/j.ejmech.2020.112998. Epub 2020 Nov 7. Eur J Med Chem. 2021. PMID: 33199154
Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2.
Marek M, Ramos-Morales E, Picchi-Constante GFA, Bayer T, Norström C, Herp D, Sales-Junior PA, Guerra-Slompo EP, Hausmann K, Chakrabarti A, Shaik TB, Merz A, Troesch E, Schmidtkunz K, Goldenberg S, Pierce RJ, Mourão MM, Jung M, Schultz J, Sippl W, Zanchin NIT, Romier C. Marek M, et al. Among authors: schmidtkunz k. Cell Rep. 2021 Dec 21;37(12):110129. doi: 10.1016/j.celrep.2021.110129. Cell Rep. 2021. PMID: 34936867 Free article.
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
Rumpf T, Schiedel M, Karaman B, Roessler C, North BJ, Lehotzky A, Oláh J, Ladwein KI, Schmidtkunz K, Gajer M, Pannek M, Steegborn C, Sinclair DA, Gerhardt S, Ovádi J, Schutkowski M, Sippl W, Einsle O, Jung M. Rumpf T, et al. Among authors: schmidtkunz k. Nat Commun. 2015 Feb 12;6:6263. doi: 10.1038/ncomms7263. Nat Commun. 2015. PMID: 25672491 Free PMC article.
30 results