Application of NMI-TfCl-mediated amide bond formation in the synthesis of biologically relevant oxadiazole derivatives employing less basic (hetero)aryl amines

Mol Divers. 2022 Jun;26(3):1761-1767. doi: 10.1007/s11030-021-10275-7. Epub 2021 Jul 22.

Abstract

We herein report a modified methodology for the synthesis of some oxadiazoles linked to amides under mild conditions. The developed protocol using NMI-TfCl has been found to be effective and tolerant for the amide bond formation reaction of a series of electronically deactivating and sterically challenging amines. The antioxidant potential of the newly synthesized compounds has been evaluated at the later stage.

Keywords: Amide; Antioxidant; Oxadiazole; Synthesis.

MeSH terms

  • Amides / chemistry
  • Amines* / chemistry
  • Oxadiazoles* / chemistry

Substances

  • Amides
  • Amines
  • Oxadiazoles