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DHHC7-mediated palmitoylation of the accessory protein barttin critically regulates the functions of ClC-K chloride channels.
Gorinski N, Wojciechowski D, Guseva D, Abdel Galil D, Mueller FE, Wirth A, Thiemann S, Zeug A, Schmidt S, Zareba-Kozioł M, Wlodarczyk J, Skryabin BV, Glage S, Fischer M, Al-Samir S, Kerkenberg N, Hohoff C, Zhang W, Endeward V, Ponimaskin E. Gorinski N, et al. J Biol Chem. 2020 May 1;295(18):5970-5983. doi: 10.1074/jbc.RA119.011049. Epub 2020 Mar 17. J Biol Chem. 2020. PMID: 32184353 Free PMC article.
Barttin is the accessory subunit of the human ClC-K chloride channels, which are expressed in both the kidney and inner ear. Barttin promotes trafficking of the complex it forms with ClC-K to the plasma membrane and is involved in activating this channel. ...
Barttin is the accessory subunit of the human ClC-K chloride channels, which are expressed in both the kidney and inner ear. Barttin …
Oligomerization and Spatial Distribution of Kvβ1.1 and Kvβ2.1 Regulatory Subunits.
Roig SR, Cassinelli S, Zeug A, Ponimaskin E, Felipe A. Roig SR, et al. Front Physiol. 2022 Jun 17;13:930769. doi: 10.3389/fphys.2022.930769. eCollection 2022. Front Physiol. 2022. PMID: 35784882 Free PMC article.
Members of the regulatory Kvbeta family modulate the kinetics and traffic of voltage-dependent K(+) (Kv) channels. The crystal structure of Kv channels associated with Kvbeta peptides suggests a alpha4/beta4 composition. ...
Members of the regulatory Kvbeta family modulate the kinetics and traffic of voltage-dependent K(+) (Kv) channels. The crystal struct …
Calcium-sensing receptor regulates intestinal dipeptide absorption via Ca2+ signaling and IKCa activation.
Xu J, Zeug A, Riederer B, Yeruva S, Griesbeck O, Daniel H, Tuo B, Ponimaskin E, Dong H, Seidler U. Xu J, et al. Physiol Rep. 2020 Jan;8(1):e14337. doi: 10.14814/phy2.14337. Physiol Rep. 2020. PMID: 31960592 Free PMC article.
Clotrimazole and TRM-34, two selective blockers of the intermediate conductance Ca(2+) -activated K(+) channel (IK(Ca) ), but not iberiotoxin, a selective blocker of the large-conductance K(+) channel (BK(Ca) ) and apamin, a selective blocker of the small-conductanc …
Clotrimazole and TRM-34, two selective blockers of the intermediate conductance Ca(2+) -activated K(+) channel (IK(Ca) ), but not ibe …
Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers.
Hogendorf AS, Hogendorf A, Popiołek-Barczyk K, Ciechanowska A, Mika J, Satała G, Walczak M, Latacz G, Handzlik J, Kieć-Kononowicz K, Ponimaskin E, Schade S, Zeug A, Bijata M, Kubicki M, Kurczab R, Lenda T, Staroń J, Bugno R, Duszyńska B, Pilarski B, Bojarski AJ. Hogendorf AS, et al. Eur J Med Chem. 2019 May 15;170:261-275. doi: 10.1016/j.ejmech.2019.03.017. Epub 2019 Mar 11. Eur J Med Chem. 2019. PMID: 30904783
A potent and drug-like agonist, 3-(1-ethyl-1H-imidazol-5-yl)-5-iodo-4-fluoro-1H-indole (AGH-192, 35, K(i 5-HT7)(R) = 4 nM), was identified by optimizing the halogen bond formation with Ser5.42 as the supposed partner. ...
A potent and drug-like agonist, 3-(1-ethyl-1H-imidazol-5-yl)-5-iodo-4-fluoro-1H-indole (AGH-192, 35, K(i 5-HT7)(R) = 4 nM), was ident …
Scintillation light detection in the 6-m drift-length ProtoDUNE Dual Phase liquid argon TPC.
Abud AA, Abi B, Acciarri R, Acero MA, Adames MR, Adamov G, Adamowski M, Adams D, Adinolfi M, Aduszkiewicz A, Aguilar J, Ahmad Z, Ahmed J, Aimard B, Ali-Mohammadzadeh B, Alion T, Allison K, Monsalve SA, AlRashed M, Alt C, Alton A, Alvarez R, Amedo P, Anderson J, Andreopoulos C, Andreotti M, Andrews M, Andrianala F, Andringa S, Anfimov N, Ankowski A, Antoniassi M, Antonova M, Antoshkin A, Antusch S, Aranda-Fernandez A, Arellano L, Arnold LO, Arroyave MA, Asaadi J, Asquith L, Aurisano A, Aushev V, Autiero D, Lara VA, Ayala-Torres M, Azfar F, Back A, Back H, Back JJ, Backhouse C, Bagaturia I, Bagby L, Balashov N, Balasubramanian S, Baldi P, Baller B, Bambah B, Barao F, Barenboim G, Alzas PB, Barker G, Barkhouse W, Barnes C, Barr G, Monarca JB, Barros A, Barros N, Barrow JL, Basharina-Freshville A, Bashyal A, Basque V, Batchelor C, Chagas EBD, Battat JBR, Battisti F, Bay F, Bazetto MCQ, Alba JLLB, Beacom JF, Bechetoille E, Behera B, Beigbeder C, Bellantoni L, Bellettini G, Bellini V, Beltramello O, Benekos N, Montiel CB, Neves FB, Berger J, Berkman S, Bernardini P, Berner RM, Bersani A, Bertolucci S, Betancourt M, Rodríguez AB, Bevan A, Bezawada Y, Bezerra TJC, Bhardwaj A, Bhatnagar V,… See abstract for full author list ➔ Abud AA, et al. Eur Phys J C Part Fields. 2022;82(7):618. doi: 10.1140/epjc/s10052-022-10549-w. Epub 2022 Jul 16. Eur Phys J C Part Fields. 2022. PMID: 35859696 Free PMC article.
P21/c Postorthopyroxene γ-LiScGe2O6, a New Dense High-Pressure Polymorph and Its Direct Transformation from the Pbca Structure.
Ende M, Meusburger JM, Zeug M, Scheidl KS, Redhammer GJ, Miletich R. Ende M, et al. Inorg Chem. 2020 Dec 21;59(24):17981-17991. doi: 10.1021/acs.inorgchem.0c02284. Epub 2020 Nov 27. Inorg Chem. 2020. PMID: 33245665 Free PMC article.
The fit of the unit-cell volumes of beta-LiScGe(2)O(6), using a third-order Birch-Murnaghan equation of state, yields V(0) = 943.63 0.11 A(3), K(0) = 89.8 0.6 GPa, and dK/dP = 4.75 0.18 as parameters. Evaluation of the data points beyond the critical transition pressure us …
The fit of the unit-cell volumes of beta-LiScGe(2)O(6), using a third-order Birch-Murnaghan equation of state, yields V(0) = 943.63 0.11 A(3 …
Prospects for beyond the Standard Model physics searches at the Deep Underground Neutrino Experiment: DUNE Collaboration.
Abi B, Acciarri R, Acero MA, Adamov G, Adams D, Adinolfi M, Ahmad Z, Ahmed J, Alion T, Monsalve SA, Alt C, Anderson J, Andreopoulos C, Andrews MP, Andrianala F, Andringa S, Ankowski A, Antonova M, Antusch S, Aranda-Fernandez A, Ariga A, Arnold LO, Arroyave MA, Asaadi J, Aurisano A, Aushev V, Autiero D, Azfar F, Back H, Back JJ, Backhouse C, Baesso P, Bagby L, Bajou R, Balasubramanian S, Baldi P, Bambah B, Barao F, Barenboim G, Barker GJ, Barkhouse W, Barnes C, Barr G, Monarca JB, Barros N, Barrow JL, Bashyal A, Basque V, Bay F, Alba JLB, Beacom JF, Bechetoille E, Behera B, Bellantoni L, Bellettini G, Bellini V, Beltramello O, Belver D, Benekos N, Neves FB, Berger J, Berkman S, Bernardini P, Berner RM, Berns H, Bertolucci S, Betancourt M, Bezawada Y, Bhattacharjee M, Bhuyan B, Biagi S, Bian J, Biassoni M, Biery K, Bilki B, Bishai M, Bitadze A, Blake A, Siffert BB, Blaszczyk FDM, Blazey GC, Blucher E, Boissevain J, Bolognesi S, Bolton T, Bonesini M, Bongrand M, Bonini F, Booth A, Booth C, Bordoni S, Borkum A, Boschi T, Bostan N, Bour P, Boyd SB, Boyden D, Bracinik J, Braga D, Brailsford D, Brandt A, Bremer J, Brew C, Brianne E, Brice SJ, Brizzolari C, Bromberg C, Brooijmans G, Brook… See abstract for full author list ➔ Abi B, et al. Eur Phys J C Part Fields. 2021;81(4):322. doi: 10.1140/epjc/s10052-021-09007-w. Epub 2021 Apr 16. Eur Phys J C Part Fields. 2021. PMID: 34720713 Free PMC article.