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Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive Function: A Meta-analysis of Community-Based Cohorts.
Neurology. 2023 May 2;100(18):e1930-e1943. doi: 10.1212/WNL.0000000000207157. Epub 2023 Mar 16.
Neurology. 2023.
PMID: 36927883
Repurposing p97 inhibitors for chemical modulation of the bacterial ClpB-DnaK bichaperone system.
Glaza P, Ranaweera CB, Shiva S, Roy A, Geisbrecht BV, Schoenen FJ, Zolkiewski M.
Glaza P, et al.
J Biol Chem. 2021 Jan-Jun;296:100079. doi: 10.1074/jbc.RA120.015413. Epub 2020 Nov 21.
J Biol Chem. 2021.
PMID: 33187983
Free PMC article.
We discovered that N(2),N(4)-dibenzylquinazoline-2,4-diamine (DBeQ), the least potent among the tested p97 inhibitors, binds to ClpB with a K(d)60 muM and inhibits the casein-activated, but not the basal, ATPase activity of ClpB with an IC(50)5 muM. The remaining p9 …
We discovered that N(2),N(4)-dibenzylquinazoline-2,4-diamine (DBeQ), the least potent among the tested p97 inhibitors, binds to ClpB with a …
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Authentication of the geographical origin of Australian Cabernet Sauvignon wines using spectrofluorometric and multi-element analyses with multivariate statistical modelling.
Ranaweera RKR, Gilmore AM, Capone DL, Bastian SEP, Jeffery DW.
Ranaweera RKR, et al.
Food Chem. 2021 Jan 15;335:127592. doi: 10.1016/j.foodchem.2020.127592. Epub 2020 Jul 17.
Food Chem. 2021.
PMID: 32750629
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Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis.
Kirane A, Ludwig KF, Sorrelle N, Haaland G, Sandal T, Ranaweera R, Toombs JE, Wang M, Dineen SP, Micklem D, Dellinger MT, Lorens JB, Brekken RA.
Kirane A, et al.
Cancer Res. 2015 Sep 15;75(18):3699-705. doi: 10.1158/0008-5472.CAN-14-2887-T. Epub 2015 Jul 23.
Cancer Res. 2015.
PMID: 26206560
Free PMC article.
Repurposing "old" drugs can facilitate rapid clinical translation but necessitates novel mechanistic insight. Warfarin, a vitamin K "antagonist" used clinically for the prevention of thrombosis for more than 50 years, has been shown to have anticancer effects. We hypothesi …
Repurposing "old" drugs can facilitate rapid clinical translation but necessitates novel mechanistic insight. Warfarin, a vitamin K " …
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