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Key metalloproteinase-mediated pathways in the kidney.
Wozniak J, Floege J, Ostendorf T, Ludwig A. Wozniak J, et al. Nat Rev Nephrol. 2021 Aug;17(8):513-527. doi: 10.1038/s41581-021-00415-5. Epub 2021 Apr 20. Nat Rev Nephrol. 2021. PMID: 33879883 Review.
The metalloproteinase ADAM10 requires its activity to sustain surface expression.
Seifert A, Düsterhöft S, Wozniak J, Koo CZ, Tomlinson MG, Nuti E, Rossello A, Cuffaro D, Yildiz D, Ludwig A. Seifert A, et al. Among authors: wozniak j. Cell Mol Life Sci. 2021 Jan;78(2):715-732. doi: 10.1007/s00018-020-03507-w. Epub 2020 May 5. Cell Mol Life Sci. 2021. PMID: 32372373 Free PMC article.
A structural model of the iRhom-ADAM17 sheddase complex reveals functional insights into its trafficking and activity.
Kahveci-Türköz S, Bläsius K, Wozniak J, Rinkens C, Seifert A, Kasparek P, Ohm H, Oltzen S, Nieszporek M, Schwarz N, Babendreyer A, Preisinger C, Sedlacek R, Ludwig A, Düsterhöft S. Kahveci-Türköz S, et al. Among authors: wozniak j. Cell Mol Life Sci. 2023 Apr 29;80(5):135. doi: 10.1007/s00018-023-04783-y. Cell Mol Life Sci. 2023. PMID: 37119365 Free PMC article.
The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release.
Düsterhöft S, Kahveci-Türköz S, Wozniak J, Seifert A, Kasparek P, Ohm H, Liu S, Kopkanova J, Lokau J, Garbers C, Preisinger C, Sedlacek R, Freeman M, Ludwig A. Düsterhöft S, et al. Among authors: wozniak j. Cell Mol Life Sci. 2021 Jun;78(11):5015-5040. doi: 10.1007/s00018-021-03845-3. Epub 2021 May 5. Cell Mol Life Sci. 2021. PMID: 33950315 Free PMC article.
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