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Page 1
From a Cone Snail Toxin to a Competitive MC4R Antagonist.
Reynaud S, Laurin SA, Ciolek J, Barbe P, Van Baelen AC, Susset M, Blondel F, Ghazarian M, Boeri J, Vanden Driessche M, Upert G, Mourier G, Kessler P, Konnert L, Beroud R, Keck M, Servent D, Bouvier M, Gilles N. Reynaud S, et al. Among authors: ciolek j. J Med Chem. 2022 Sep 22;65(18):12084-12094. doi: 10.1021/acs.jmedchem.2c00786. Epub 2022 Sep 5. J Med Chem. 2022. PMID: 36063022
A new Kunitz-type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor.
Droctové L, Ciolek J, Mendre C, Chorfa A, Huerta P, Carvalho C, Gouin C, Lancien M, Stanajic-Petrovic G, Braco L, Blanchet G, Upert G, De Pauw G, Barbe P, Keck M, Mourier G, Mouillac B, Denis S, Rodríguez de la Vega RC, Quinton L, Gilles N. Droctové L, et al. Among authors: ciolek j. Br J Pharmacol. 2022 Jul;179(13):3470-3481. doi: 10.1111/bph.15814. Epub 2022 Feb 28. Br J Pharmacol. 2022. PMID: 35122240 Free article.
A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists.
Reynaud S, Ciolek J, Degueldre M, Saez NJ, Sequeira AF, Duhoo Y, Brás JLA, Meudal H, Cabo Díez M, Fernández Pedrosa V, Verdenaud M, Boeri J, Pereira Ramos O, Ducancel F, Vanden Driessche M, Fourmy R, Violette A, Upert G, Mourier G, Beck-Sickinger AG, Mörl K, Landon C, Fontes CMGA, Miñambres Herráiz R, Rodríguez de la Vega RC, Peigneur S, Tytgat J, Quinton L, De Pauw E, Vincentelli R, Servent D, Gilles N. Reynaud S, et al. Among authors: ciolek j. J Med Chem. 2020 Aug 13;63(15):8250-8264. doi: 10.1021/acs.jmedchem.0c00485. Epub 2020 Jul 16. J Med Chem. 2020. PMID: 32602722
MT9, a natural peptide from black mamba venom antagonizes the muscarinic type 2 receptor and reverses the M2R-agonist-induced relaxation in rat and human arteries.
Ciolek J, Zoukimian C, Dhot J, Burban M, Triquigneaux M, Lauzier B, Guimbert C, Boturyn D, Ferron M, Ciccone L, Tepshi L, Stura E, Legrand P, Robin P, Mourier G, Schaack B, Fellah I, Blanchet G, Gauthier-Erfanian C, Beroud R, Servent D, De Waard M, Gilles N. Ciolek J, et al. Biomed Pharmacother. 2022 Jun;150:113094. doi: 10.1016/j.biopha.2022.113094. Epub 2022 May 10. Biomed Pharmacother. 2022. PMID: 35658242 Free article.
Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease.
Ciolek J, Reinfrank H, Quinton L, Viengchareun S, Stura EA, Vera L, Sigismeau S, Mouillac B, Orcel H, Peigneur S, Tytgat J, Droctové L, Beau F, Nevoux J, Lombès M, Mourier G, De Pauw E, Servent D, Mendre C, Witzgall R, Gilles N. Ciolek J, et al. Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7154-7159. doi: 10.1073/pnas.1620454114. Epub 2017 Jun 19. Proc Natl Acad Sci U S A. 2017. PMID: 28630289 Free PMC article.