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Page 1
From a Cone Snail Toxin to a Competitive MC4R Antagonist.
J Med Chem. 2022 Sep 22;65(18):12084-12094. doi: 10.1021/acs.jmedchem.2c00786. Epub 2022 Sep 5.
J Med Chem. 2022.
PMID: 36063022
A new Kunitz-type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor.
Droctové L, Ciolek J, Mendre C, Chorfa A, Huerta P, Carvalho C, Gouin C, Lancien M, Stanajic-Petrovic G, Braco L, Blanchet G, Upert G, De Pauw G, Barbe P, Keck M, Mourier G, Mouillac B, Denis S, Rodríguez de la Vega RC, Quinton L, Gilles N.
Droctové L, et al. Among authors: ciolek j.
Br J Pharmacol. 2022 Jul;179(13):3470-3481. doi: 10.1111/bph.15814. Epub 2022 Feb 28.
Br J Pharmacol. 2022.
PMID: 35122240
Free article.
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A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists.
Reynaud S, Ciolek J, Degueldre M, Saez NJ, Sequeira AF, Duhoo Y, Brás JLA, Meudal H, Cabo Díez M, Fernández Pedrosa V, Verdenaud M, Boeri J, Pereira Ramos O, Ducancel F, Vanden Driessche M, Fourmy R, Violette A, Upert G, Mourier G, Beck-Sickinger AG, Mörl K, Landon C, Fontes CMGA, Miñambres Herráiz R, Rodríguez de la Vega RC, Peigneur S, Tytgat J, Quinton L, De Pauw E, Vincentelli R, Servent D, Gilles N.
Reynaud S, et al. Among authors: ciolek j.
J Med Chem. 2020 Aug 13;63(15):8250-8264. doi: 10.1021/acs.jmedchem.0c00485. Epub 2020 Jul 16.
J Med Chem. 2020.
PMID: 32602722
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MT9, a natural peptide from black mamba venom antagonizes the muscarinic type 2 receptor and reverses the M2R-agonist-induced relaxation in rat and human arteries.
Ciolek J, Zoukimian C, Dhot J, Burban M, Triquigneaux M, Lauzier B, Guimbert C, Boturyn D, Ferron M, Ciccone L, Tepshi L, Stura E, Legrand P, Robin P, Mourier G, Schaack B, Fellah I, Blanchet G, Gauthier-Erfanian C, Beroud R, Servent D, De Waard M, Gilles N.
Ciolek J, et al.
Biomed Pharmacother. 2022 Jun;150:113094. doi: 10.1016/j.biopha.2022.113094. Epub 2022 May 10.
Biomed Pharmacother. 2022.
PMID: 35658242
Free article.
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Evaluation of the Spider (Phlogiellus genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug Candidates.
Gonçalves TC, Lesport P, Kuylle S, Stura E, Ciolek J, Mourier G, Servent D, Bourinet E, Benoit E, Gilles N.
Gonçalves TC, et al. Among authors: ciolek j.
Toxins (Basel). 2019 Aug 22;11(9):484. doi: 10.3390/toxins11090484.
Toxins (Basel). 2019.
PMID: 31443554
Free PMC article.
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Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease.
Ciolek J, Reinfrank H, Quinton L, Viengchareun S, Stura EA, Vera L, Sigismeau S, Mouillac B, Orcel H, Peigneur S, Tytgat J, Droctové L, Beau F, Nevoux J, Lombès M, Mourier G, De Pauw E, Servent D, Mendre C, Witzgall R, Gilles N.
Ciolek J, et al.
Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7154-7159. doi: 10.1073/pnas.1620454114. Epub 2017 Jun 19.
Proc Natl Acad Sci U S A. 2017.
PMID: 28630289
Free PMC article.
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Pharmacological characterization of zinc and copper interaction with the human alpha(1A)-adrenoceptor.
Ciolek J, Maïga A, Marcon E, Servent D, Gilles N.
Ciolek J, et al.
Eur J Pharmacol. 2011 Mar 25;655(1-3):1-8. doi: 10.1016/j.ejphar.2010.12.042. Epub 2011 Jan 22.
Eur J Pharmacol. 2011.
PMID: 21262225
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