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Locally-applied 5-fluorouracil-loaded slow-release patch prevents pancreatic cancer growth in an orthotopic mouse model.
Shim IK, Yi HJ, Yi HG, Lee CM, Lee YN, Choi YJ, Jeong SY, Jun E, Hoffman RM, Cho DW, Kim SC. Shim IK, et al. Oncotarget. 2017 Jun 20;8(25):40140-40151. doi: 10.18632/oncotarget.17370. Oncotarget. 2017. PMID: 28498800 Free PMC article.
Luciferase imaging of BxPC3-Luc cells implanted in the pancreas was performed longitudinally. The drug patch delivered a 30.2 times higher level of 5-FU than an intra-peritoneal (i.p.) bolus injection on day-1. High 5-FU levels were accumulated within one week by th …
Luciferase imaging of BxPC3-Luc cells implanted in the pancreas was performed longitudinally. The drug patch delivered a 30.2 times higher l …
Controversial benefit of 5-fluorouracil/leucovorin-based adjuvant chemotherapy for ampullary cancer: a propensity score-matched analysis.
Kang J, Lee W, Shin J, Park Y, Kwon JW, Jun E, Song KB, Lee JH, Hwang DW, Park SY, Kim SC. Kang J, et al. Langenbecks Arch Surg. 2022 May;407(3):1091-1097. doi: 10.1007/s00423-021-02414-3. Epub 2022 Jan 10. Langenbecks Arch Surg. 2022. PMID: 35013798
CONCLUSION: Patients who received adjuvant chemotherapy based on 5-FU/LV showed comparable oncologic outcomes to patients in the OB group even after stratification by tumor stage. The patients with intestinal subtype showed oncologic benefit for adjuvant 5-FU/LV CTx …
CONCLUSION: Patients who received adjuvant chemotherapy based on 5-FU/LV showed comparable oncologic outcomes to patients in the OB g …
The identification of candidate effective combination regimens for pancreatic cancer using the histoculture drug response assay.
Jun E, Park Y, Lee W, Kwon J, Lee S, Kim MB, Lee JS, Song KB, Hwang DW, Lee JH, Hoffman RM, Kim SC. Jun E, et al. Sci Rep. 2020 Jul 20;10(1):12004. doi: 10.1038/s41598-020-68703-x. Sci Rep. 2020. PMID: 32686712 Free PMC article.
First, combination drug regimens showed higher drug efficacy and less patient variation than single drugs. Initially, 5-Fluorouracil(5-FU)/Belotecan/Oxaliplatinum and Tegafur/Gimeracil (TS-1)/Oxaliplatinum/Irinotecan were found to be effective. Second, we were able to corr …
First, combination drug regimens showed higher drug efficacy and less patient variation than single drugs. Initially, 5-Fluorouracil(5-FU …
Synergistic effect of a drug loaded electrospun patch and systemic chemotherapy in pancreatic cancer xenograft.
Jun E, Kim SC, Lee CM, Oh J, Lee S, Shim IK. Jun E, et al. Sci Rep. 2017 Sep 28;7(1):12381. doi: 10.1038/s41598-017-12670-3. Sci Rep. 2017. PMID: 28959053 Free PMC article.
The 5-FU patch directly adhered to the tumour in subcutaneous and orthotopic murine models, and induced a significant decrease in tumour size. Systemic gemcitabine treatment group, 5-FU drug releasing patch group, and systemic gemcitabine plus 5-FU patch grou …
The 5-FU patch directly adhered to the tumour in subcutaneous and orthotopic murine models, and induced a significant decrease in tum …
Change of the expression of human telomerase reverse transcriptase mRNA and human telomerase RNA after cisplatin and 5-fluorouracil exposure in head and neck squamous cell carcinoma cell lines.
Lee BJ, Lee BH, Wang SG, Lee JC, Roh HJ, Goh EK, Kim CM, Jun ES. Lee BJ, et al. J Korean Med Sci. 2007 Sep;22 Suppl(Suppl):S73-8. doi: 10.3346/jkms.2007.22.S.S73. J Korean Med Sci. 2007. PMID: 17923759 Free PMC article.
Cell cytotoxicity, the change of telomerase activity, and hTERT mRNA and hTR expression by 5-FU and cisplatin exposure were assessed by MTT assay, TRAP assay, and real-time RT-PCR, respectively. ...However, in both cell lines, the telomerase activity and hTR did not show a …
Cell cytotoxicity, the change of telomerase activity, and hTERT mRNA and hTR expression by 5-FU and cisplatin exposure were assessed …