Prevention of Anti-HMGCR Immune-Mediated Necrotising Myopathy by C5 Complement Inhibition in a Humanised Mouse Model.
Julien S, Vadysirisack D, Sayegh C, Ragunathan S, Tang Y, Briand E, Carrette M, Jean L, Zoubairi R, Gondé H, Benveniste O, Allenbach Y, Drouot L, Boyer O.
Julien S, et al.
Biomedicines. 2022 Aug 20;10(8):2036. doi: 10.3390/biomedicines10082036.
Biomedicines. 2022.
PMID: 36009583
Free PMC article.
Interventional treatment of zilucoplan after disease induction reduced the complement deposits and number of regenerated myofibres in muscles of Rag2(-/-) mice, although to a lesser extent. In this latter setting, C5 inhibition did not significantly ameliorate muscle stren …
Interventional treatment of zilucoplan after disease induction reduced the complement deposits and number of regenerated myofibres in muscle …