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Page 1
Hypoxia induces rapid changes to histone methylation and reprograms chromatin.
Science. 2019 Mar 15;363(6432):1222-1226. doi: 10.1126/science.aau5870. Epub 2019 Mar 14.
Science. 2019.
PMID: 30872526
Roles of HIF and 2-Oxoglutarate-Dependent Dioxygenases in Controlling Gene Expression in Hypoxia.
Frost J, Frost M, Batie M, Jiang H, Rocha S.
Frost J, et al.
Cancers (Basel). 2021 Jan 19;13(2):350. doi: 10.3390/cancers13020350.
Cancers (Basel). 2021.
PMID: 33477877
Free PMC article.
Review.
Item in Clipboard
Regulation of chromatin accessibility by hypoxia and HIF.
Batie M, Frost J, Shakir D, Rocha S.
Batie M, et al. Among authors: frost j.
Biochem J. 2022 Mar 31;479(6):767-786. doi: 10.1042/BCJ20220008.
Biochem J. 2022.
PMID: 35258521
Free PMC article.
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Von Hippel-Lindau (VHL) small-molecule inhibitor binding increases stability and intracellular levels of VHL protein.
Frost J, Rocha S, Ciulli A.
Frost J, et al.
J Biol Chem. 2021 Aug;297(2):100910. doi: 10.1016/j.jbc.2021.100910. Epub 2021 Jun 24.
J Biol Chem. 2021.
PMID: 34174286
Free PMC article.
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Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition.
Frost J, Galdeano C, Soares P, Gadd MS, Grzes KM, Ellis L, Epemolu O, Shimamura S, Bantscheff M, Grandi P, Read KD, Cantrell DA, Rocha S, Ciulli A.
Frost J, et al.
Nat Commun. 2016 Nov 4;7:13312. doi: 10.1038/ncomms13312.
Nat Commun. 2016.
PMID: 27811928
Free PMC article.
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RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response.
Frost J, Ciulli A, Rocha S.
Frost J, et al.
Wellcome Open Res. 2019 Jan 29;4:17. doi: 10.12688/wellcomeopenres.15044.1. eCollection 2019.
Wellcome Open Res. 2019.
PMID: 30801039
Free PMC article.
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Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298).
Soares P, Gadd MS, Frost J, Galdeano C, Ellis L, Epemolu O, Rocha S, Read KD, Ciulli A.
Soares P, et al. Among authors: frost j.
J Med Chem. 2018 Jan 25;61(2):599-618. doi: 10.1021/acs.jmedchem.7b00675. Epub 2017 Sep 18.
J Med Chem. 2018.
PMID: 28853884
Free PMC article.
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