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Osteopontin depletion in macrophages perturbs proteostasis via regulating UCHL1-UPS axis and mitochondria-mediated apoptosis.
Rentsendorj A, Raedschelders K, Fuchs DT, Sheyn J, Vaibhav V, Porritt RA, Shi H, Dagvadorj J, de Freitas Germano J, Koronyo Y, Arditi M, Black KL, Gaire BP, Van Eyk JE, Koronyo-Hamaoui M. Rentsendorj A, et al. Among authors: de freitas germano j. Front Immunol. 2023 May 30;14:1155935. doi: 10.3389/fimmu.2023.1155935. eCollection 2023. Front Immunol. 2023. PMID: 37325640 Free PMC article.
At the heart of mitochondrial quality control: many roads to the top.
Gottlieb RA, Piplani H, Sin J, Sawaged S, Hamid SM, Taylor DJ, de Freitas Germano J. Gottlieb RA, et al. Among authors: de freitas germano j. Cell Mol Life Sci. 2021 Apr;78(8):3791-3801. doi: 10.1007/s00018-021-03772-3. Epub 2021 Feb 5. Cell Mol Life Sci. 2021. PMID: 33544154 Free PMC article. Review.
Cytolethal distending toxin B inoculation leads to distinct gut microtypes and IBS-D-like microRNA-mediated gene expression changes in a rodent model.
Leite G, de Freitas Germano J, Morales W, Weitsman S, Barlow GM, Parodi G, Pimentel ML, Villanueva-Millan MJ, Sanchez M, Ayyad S, Rezaie A, Mathur R, Pimentel M. Leite G, et al. Among authors: de freitas germano j. Gut Microbes. 2024 Jan-Dec;16(1):2293170. doi: 10.1080/19490976.2023.2293170. Epub 2023 Dec 18. Gut Microbes. 2024. PMID: 38108386 Free PMC article.
Asporin, an extracellular matrix protein, is a beneficial regulator of cardiac remodeling.
Huang C, Sharma A, Thakur R, Rai D, Katiki M, Germano JF, Song Y, Singh S, Sin J, Sengstock D, Andres AM, Murali R, Mentzer RM Jr, Gottlieb RA, Piplani H. Huang C, et al. Among authors: germano jf. Matrix Biol. 2022 Jun;110:40-59. doi: 10.1016/j.matbio.2022.04.005. Epub 2022 Apr 22. Matrix Biol. 2022. PMID: 35470068 Free PMC article.
Simvastatin induces autophagic flux to restore cerulein-impaired phagosome-lysosome fusion in acute pancreatitis.
Piplani H, Marek-Iannucci S, Sin J, Hou J, Takahashi T, Sharma A, de Freitas Germano J, Waldron RT, Saadaeijahromi H, Song Y, Gulla A, Wu B, Lugea A, Andres AM, Gaisano HY, Gottlieb RA, Pandol SJ. Piplani H, et al. Among authors: de freitas germano j. Biochim Biophys Acta Mol Basis Dis. 2019 Nov 1;1865(11):165530. doi: 10.1016/j.bbadis.2019.08.006. Epub 2019 Aug 6. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 31398467 Free article.
ABCC3 Polymorphisms and mRNA Expression Influence the Concentration of a Carboxylic Acid Metabolite in Patients on Clopidogrel and Aspirin Therapy.
Luchessi AD, Concheiro M, Germano JF, Silbiger VN, Bortolin RH, Cruz A, Quintela O, Brion M, Carracedo A, Iñiguez A, Bravo M, López-Rivadulla M, Hirata RD, Sousa AG, Hirata MH. Luchessi AD, et al. Among authors: germano jf. Basic Clin Pharmacol Toxicol. 2017 May;120(5):466-474. doi: 10.1111/bcpt.12703. Epub 2017 Jan 16. Basic Clin Pharmacol Toxicol. 2017. PMID: 27862978 Free article.