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Pertuzumab increases epidermal growth factor receptor down-regulation by counteracting epidermal growth factor receptor-ErbB2 heterodimerization.
Mol Cancer Ther. 2009 Jul;8(7):1885-92. doi: 10.1158/1535-7163.MCT-09-0291. Epub 2009 Jul 7.
Mol Cancer Ther. 2009.
PMID: 19584234
Pertuzumab Increases 17-AAG-Induced Degradation of ErbB2, and This Effect Is Further Increased by Combining Pertuzumab with Trastuzumab.
Hughes JB, Rødland MS, Hasmann M, Madshus IH, Stang E.
Hughes JB, et al.
Pharmaceuticals (Basel). 2012 Jun 28;5(7):674-89. doi: 10.3390/ph5070674.
Pharmaceuticals (Basel). 2012.
PMID: 24281706
Free PMC article.
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