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MYT1L haploinsufficiency in human neurons and mice causes autism-associated phenotypes that can be reversed by genetic and pharmacologic intervention.
Weigel B, Tegethoff JF, Grieder SD, Lim B, Nagarajan B, Liu YC, Truberg J, Papageorgiou D, Adrian-Segarra JM, Schmidt LK, Kaspar J, Poisel E, Heinzelmann E, Saraswat M, Christ M, Arnold C, Ibarra IL, Campos J, Krijgsveld J, Monyer H, Zaugg JB, Acuna C, Mall M. Weigel B, et al. Among authors: adrian segarra jm. Mol Psychiatry. 2023 May;28(5):2122-2135. doi: 10.1038/s41380-023-01959-7. Epub 2023 Feb 14. Mol Psychiatry. 2023. PMID: 36782060 Free PMC article.
Pro-neuronal activity of Myod1 due to promiscuous binding to neuronal genes.
Lee QY, Mall M, Chanda S, Zhou B, Sharma KS, Schaukowitch K, Adrian-Segarra JM, Grieder SD, Kareta MS, Wapinski OL, Ang CE, Li R, Südhof TC, Chang HY, Wernig M. Lee QY, et al. Among authors: adrian segarra jm. Nat Cell Biol. 2020 Apr;22(4):401-411. doi: 10.1038/s41556-020-0490-3. Epub 2020 Mar 30. Nat Cell Biol. 2020. PMID: 32231311
Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1.
Fang J, Ianni A, Smolka C, Vakhrusheva O, Nolte H, Krüger M, Wietelmann A, Simonet NG, Adrian-Segarra JM, Vaquero A, Braun T, Bober E. Fang J, et al. Among authors: adrian segarra jm. Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8352-E8361. doi: 10.1073/pnas.1706945114. Epub 2017 Sep 18. Proc Natl Acad Sci U S A. 2017. PMID: 28923965 Free PMC article.
12 results