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Efficacy and safety of two whole IgG polyvalent antivenoms, refined by caprylic acid fractionation with or without beta-propiolactone, in the treatment of Bothrops asper bites in Colombia.
Otero R, León G, Gutiérrez JM, Rojas G, Toro MF, Barona J, Rodríguez V, Díaz A, Núñez V, Quintana JC, Ayala S, Mosquera D, Conrado LL, Fernández D, Arroyo Y, Paniagua CA, López M, Ospina CE, Alzate C, Fernández J, Meza JJ, Silva JF, Ramírez P, Fabra PE, Ramírez E, Córdoba E, Arrieta AB, Warrell DA, Theakston RD. Otero R, et al. Among authors: silva jf. Trans R Soc Trop Med Hyg. 2006 Dec;100(12):1173-82. doi: 10.1016/j.trstmh.2006.01.006. Epub 2006 May 12. Trans R Soc Trop Med Hyg. 2006. PMID: 16698053 Clinical Trial.