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Page 1
Synthesis and pharmacological evaluation of acylhydroquinone derivatives as potent antiplatelet agents.
Biochem Pharmacol. 2021 Jan;183:114341. doi: 10.1016/j.bcp.2020.114341. Epub 2020 Nov 13.
Biochem Pharmacol. 2021.
PMID: 33197432
In Vitro Effect of Mitochondria-Targeted Triphenylphosphonium-Based Compounds (Honokiol, Lonidamine, and Atovaquone) on the Platelet Function and Cytotoxic Activity.
Montecino-Garrido H, Méndez D, Araya-Maturana R, Millas-Vargas JP, Wehinger S, Fuentes E.
Montecino-Garrido H, et al. Among authors: millas vargas jp.
Front Pharmacol. 2022 May 11;13:893873. doi: 10.3389/fphar.2022.893873. eCollection 2022.
Front Pharmacol. 2022.
PMID: 35645840
Free PMC article.
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Synthesis of antiplatelet ortho-carbonyl hydroquinones with differential action on platelet aggregation stimulated by collagen or TRAP-6.
Méndez D, Urra FA, Millas-Vargas JP, Alarcón M, Rodríguez-Lavado J, Palomo I, Trostchansky A, Araya-Maturana R, Fuentes E.
Méndez D, et al. Among authors: millas vargas jp.
Eur J Med Chem. 2020 Apr 15;192:112187. doi: 10.1016/j.ejmech.2020.112187. Epub 2020 Mar 2.
Eur J Med Chem. 2020.
PMID: 32155530
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An acylhydroquinone derivative produces OXPHOS uncoupling and sensitization to BH3 mimetic ABT-199 (Venetoclax) in human promyelocytic leukemia cells.
Donoso-Bustamante V, Borrego EA, Schiaffino-Bustamante Y, Gutiérrez DA, Millas-Vargas JP, Fuentes-Retamal S, Correa P, Carrillo I, Aguilera RJ, Miranda D, Chávez-Báez I, Pulgar R, Urra FA, Varela-Ramírez A, Araya-Maturana R.
Donoso-Bustamante V, et al. Among authors: millas vargas jp.
Bioorg Chem. 2020 Jul;100:103935. doi: 10.1016/j.bioorg.2020.103935. Epub 2020 May 18.
Bioorg Chem. 2020.
PMID: 32454391
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FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway.
Urra FA, Muñoz F, Córdova-Delgado M, Ramírez MP, Peña-Ahumada B, Rios M, Cruz P, Ahumada-Castro U, Bustos G, Silva-Pavez E, Pulgar R, Morales D, Varela D, Millas-Vargas JP, Retamal E, Ramírez-Rodríguez O, Pessoa-Mahana H, Pavani M, Ferreira J, Cárdenas C, Araya-Maturana R.
Urra FA, et al. Among authors: millas vargas jp.
Sci Rep. 2018 Sep 4;8(1):13190. doi: 10.1038/s41598-018-31367-9.
Sci Rep. 2018.
PMID: 30181620
Free PMC article.
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Assessing Parameter Suitability for the Strength Evaluation of Intramolecular Resonance Assisted Hydrogen Bonding in o-Carbonyl Hydroquinones.
Martínez-Cifuentes M, Monroy-Cárdenas M, Millas-Vargas JP, Weiss-López BE, Araya-Maturana R.
Martínez-Cifuentes M, et al. Among authors: millas vargas jp.
Molecules. 2019 Jan 14;24(2):280. doi: 10.3390/molecules24020280.
Molecules. 2019.
PMID: 30646498
Free PMC article.
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Small structural changes on a hydroquinone scaffold determine the complex I inhibition or uncoupling of tumoral oxidative phosphorylation.
Urra FA, Córdova-Delgado M, Lapier M, Orellana-Manzano A, Acevedo-Arévalo L, Pessoa-Mahana H, González-Vivanco JM, Martínez-Cifuentes M, Ramírez-Rodríguez O, Millas-Vargas JP, Weiss-López B, Pavani M, Ferreira J, Araya-Maturana R.
Urra FA, et al. Among authors: millas vargas jp.
Toxicol Appl Pharmacol. 2016 Jan 15;291:46-57. doi: 10.1016/j.taap.2015.12.005. Epub 2015 Dec 19.
Toxicol Appl Pharmacol. 2016.
PMID: 26712467
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