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Page 1
Mosquito Acetylcholinesterase as a Target for Novel Phenyl-Substituted Carbamates.
Mutunga JM, Ma M, Chen QH, Hartsel JA, Wong DM, Ding S, Totrov M, Carlier PR, Bloomquist JR. Mutunga JM, et al. Among authors: hartsel ja. Int J Environ Res Public Health. 2019 Apr 28;16(9):1500. doi: 10.3390/ijerph16091500. Int J Environ Res Public Health. 2019. PMID: 31035318 Free PMC article.
Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT2 Receptor Agonist.
Varty GB, Canal CE, Mueller TA, Hartsel JA, Tyagi R, Avery K, Morgan ME, Reichelt AC, Pathare P, Stang E, Palfreyman MG, Nivorozhkin A. Varty GB, et al. Among authors: hartsel ja. J Med Chem. 2024 Apr 25;67(8):6144-6188. doi: 10.1021/acs.jmedchem.3c01961. Epub 2024 Apr 9. J Med Chem. 2024. PMID: 38593423
Aryl methylcarbamates: potency and selectivity towards wild-type and carbamate-insensitive (G119S) Anopheles gambiae acetylcholinesterase, and toxicity to G3 strain An. gambiae.
Wong DM, Li J, Lam PC, Hartsel JA, Mutunga JM, Totrov M, Bloomquist JR, Carlier PR. Wong DM, et al. Among authors: hartsel ja. Chem Biol Interact. 2013 Mar 25;203(1):314-8. doi: 10.1016/j.cbi.2012.09.001. Epub 2012 Sep 16. Chem Biol Interact. 2013. PMID: 22989775 Free PMC article.
Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase.
Hartsel JA, Wong DM, Mutunga JM, Ma M, Anderson TD, Wysinski A, Islam R, Wong EA, Paulson SL, Li J, Lam PC, Totrov MM, Bloomquist JR, Carlier PR. Hartsel JA, et al. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4593-8. doi: 10.1016/j.bmcl.2012.05.103. Epub 2012 Jun 6. Bioorg Med Chem Lett. 2012. PMID: 22738634 Free PMC article.