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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1948 2
1952 2
1953 1
1954 2
1956 4
1958 2
1959 1
1960 7
1961 10
1962 16
1963 18
1964 10
1965 4
1966 11
1967 15
1968 19
1969 11
1970 17
1971 28
1972 30
1973 27
1974 27
1975 51
1976 36
1977 75
1978 107
1979 122
1980 128
1981 124
1982 137
1983 119
1984 161
1985 158
1986 202
1987 220
1988 241
1989 277
1990 300
1991 319
1992 354
1993 355
1994 399
1995 458
1996 570
1997 565
1998 578
1999 634
2000 713
2001 779
2002 970
2003 1030
2004 1242
2005 1445
2006 1625
2007 1672
2008 1928
2009 2045
2010 2474
2011 2749
2012 3066
2013 3444
2014 3476
2015 3796
2016 3954
2017 4244
2018 4492
2019 4894
2020 5837
2021 6908
2022 7528
2023 7264
2024 2738

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77,961 results

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The following term was not found in PubMed: Joon-Keat
Page 1
Targeting UGCG Overcomes Resistance to Lysosomal Autophagy Inhibition.
Jain V, Harper SL, Versace AM, Fingerman D, Brown GS, Bhardwaj M, Crissey MAS, Goldman AR, Ruthel G, Liu Q, Zivkovic A, Stark H, Herlyn M, Gimotty PA, Speicher DW, Amaravadi RK. Jain V, et al. Cancer Discov. 2023 Feb 6;13(2):454-473. doi: 10.1158/2159-8290.CD-22-0535. Cancer Discov. 2023. PMID: 36331284 Free PMC article.
To elucidate LAI resistance, proteomics and immunoblotting demonstrated that LAI induced lipid metabolism enzymes in multiple cancer cell lines. ...Although UGCG inhibition decreased LAI-induced GMM and augmented cell death, UGCG overexpression led to LAI …
To elucidate LAI resistance, proteomics and immunoblotting demonstrated that LAI induced lipid metabolism enzymes in multiple …
Real-World Evidence of the Clinical and Economic Impact of Long-Acting Injectable Versus Oral Antipsychotics Among Patients with Schizophrenia in the United States: A Systematic Review and Meta-Analysis.
Lin D, Thompson-Leduc P, Ghelerter I, Nguyen H, Lafeuille MH, Benson C, Mavros P, Lefebvre P. Lin D, et al. CNS Drugs. 2021 May;35(5):469-481. doi: 10.1007/s40263-021-00815-y. Epub 2021 Apr 28. CNS Drugs. 2021. PMID: 33909272 Free PMC article.
In turn, the clinical benefits achieved may translate into lower economic burden. Real-world evidence of the comparative effectiveness of LAI is needed to understand the potential benefits of LAI outside of the context of clinical trials. ...Comparative studies repo …
In turn, the clinical benefits achieved may translate into lower economic burden. Real-world evidence of the comparative effectiveness of …
[LONG-ACTING INJECTABLE ANTIPSYCHOTICS IN SCHIZOPHRENIA].
Teitelbaum A, Kodesh A. Teitelbaum A, et al. Harefuah. 2019 Jul;158(7):453-457. Harefuah. 2019. PMID: 31339245 Review. Hebrew.
Several studies comparing LAI AP with oral antipsychotics in schizophrenia have been performed, in which RCTs (considered to be the 'gold standard' for clinical trial design) generally show no benefit for LAI AP over oral drugs, whereas observational studies do. The …
Several studies comparing LAI AP with oral antipsychotics in schizophrenia have been performed, in which RCTs (considered to be the ' …
Aripiprazole Lauroxil: A Review in Schizophrenia.
Frampton JE. Frampton JE. Drugs. 2017 Dec;77(18):2049-2056. doi: 10.1007/s40265-017-0848-4. Drugs. 2017. PMID: 29177572 Review.
Thus, aripiprazole lauroxil LAI extends the treatment regimen options for patients with schizophrenia; as with other LAI formulations of antipsychotic agents, it can be particularly recommended for patients with recurrent relapses related to nonadherence to oral pre …
Thus, aripiprazole lauroxil LAI extends the treatment regimen options for patients with schizophrenia; as with other LAI formu …
Personalized switching from oral to long-acting injectable second-generation antipsychotics in schizophrenia treatment using pharmacokinetic considerations.
Schoretsanitis G, Meyer JM, Conca A, Hiemke C. Schoretsanitis G, et al. Expert Opin Drug Metab Toxicol. 2023 Apr;19(4):189-202. doi: 10.1080/17425255.2023.2220962. Epub 2023 Jun 2. Expert Opin Drug Metab Toxicol. 2023. PMID: 37259573 Review.
Personalizing LAI-based therapy involves tailoring the transition from oral to LAIs based on individual and drug-related pharmacokinetic peculiarities. ...Establishing the extent of antipsychotic exposure during oral SGA-treatment from the patient's SGA levels is often a m …
Personalizing LAI-based therapy involves tailoring the transition from oral to LAIs based on individual and drug-related pharmacokine …
Therapeutic Drug Monitoring of Long-Acting Injectable Antipsychotic Drugs.
Schoretsanitis G, Baumann P, Conca A, Dietmaier O, Giupponi G, Gründer G, Hahn M, Hart X, Havemann-Reinecke U, Hefner G, Kuzin M, Mössner R, Piacentino D, Steimer W, Zernig G, Hiemke C. Schoretsanitis G, et al. Ther Drug Monit. 2021 Feb 1;43(1):79-102. doi: 10.1097/FTD.0000000000000830. Ther Drug Monit. 2021. PMID: 33196621 Review.
Reported data combined with positron emission tomography evidence indicated a trend toward lower concentrations under LAI administration than under oral medications. However, the available evidence is insufficient to recommend LAI-specific therapeutic reference rang …
Reported data combined with positron emission tomography evidence indicated a trend toward lower concentrations under LAI administrat …
Converting oral to long-acting injectable antipsychotics: a guide for the perplexed.
Meyer JM. Meyer JM. CNS Spectr. 2017 Dec;22(S1):14-28. doi: 10.1017/S1092852917000840. CNS Spectr. 2017. PMID: 29350127 Review.
Moreover, numerous meta-analyses of the existing literature indicate superiority of long-acting injectable (LAI) over oral antipsychotics when one adjusts for the greater illness severity and duration among patients in LAI antipsychotic trials. The increasing availa …
Moreover, numerous meta-analyses of the existing literature indicate superiority of long-acting injectable (LAI) over oral antipsycho …
Inspirational chemistry of bioabsorbable long-acting injectables.
Tice T. Tice T. Drug Deliv Transl Res. 2023 Feb;13(2):371-377. doi: 10.1007/s13346-022-01199-2. Epub 2022 Aug 21. Drug Deliv Transl Res. 2023. PMID: 35989401 Free PMC article.
Long-acting injectables (LAIs) have made a tremendous impact on clinical medicine. As evidence, dozens of approved LAI products are on the market. These LAI successes, in a large part, came from the clever chemistry of their materials that control drug delivery perf …
Long-acting injectables (LAIs) have made a tremendous impact on clinical medicine. As evidence, dozens of approved LAI products are o …
Resonant signals in the lithosphere-atmosphere-ionosphere coupling.
Chen CH, Sun YY, Zhang X, Gao Y, Wang F, Lin K, Tang CC, Huang R, Xu R, Liu J, Wang Y, Chen C. Chen CH, et al. Sci Rep. 2022 Aug 26;12(1):14587. doi: 10.1038/s41598-022-18887-1. Sci Rep. 2022. PMID: 36028655 Free PMC article.
An instrumental system was established in southwest China (Leshan; LESH) for monitoring vibrations and perturbations in LAI (MVP-LAI). A ground-based Global Navigation Satellite System (GNSS) receiver at the YADU station locates ~ 260 km away that continuously recei …
An instrumental system was established in southwest China (Leshan; LESH) for monitoring vibrations and perturbations in LAI (MVP-L …
Lipid based intramuscular long-acting injectables: Current state of the art.
Wilkinson J, Ajulo D, Tamburrini V, Gall GL, Kimpe K, Holm R, Belton P, Qi S. Wilkinson J, et al. Eur J Pharm Sci. 2022 Nov 1;178:106253. doi: 10.1016/j.ejps.2022.106253. Epub 2022 Jul 3. Eur J Pharm Sci. 2022. PMID: 35793750 Free article. Review.
Long acting injectables (LAI) have received increased research and commercial interest due to their potential for improving treatment effectiveness and adherence for antipsychotic, antiviral and addiction treatments. A range of materials have been used to formulate LAI …
Long acting injectables (LAI) have received increased research and commercial interest due to their potential for improving treatment …
77,961 results
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