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Showing results for jonas linker
Your search for Jonas Hinker retrieved no results
Cerebrospinal fluid findings in COVID-19 patients with neurological symptoms.
Neumann B, Schmidbauer ML, Dimitriadis K, Otto S, Knier B, Niesen WD, Hosp JA, Günther A, Lindemann S, Nagy G, Steinberg T, Linker RA, Hemmer B, Bösel J; PANDEMIC and the IGNITE study groups. Neumann B, et al. J Neurol Sci. 2020 Nov 15;418:117090. doi: 10.1016/j.jns.2020.117090. Epub 2020 Aug 11. J Neurol Sci. 2020. PMID: 32805440 Free PMC article.
Comparison of Five Near-Infrared Fluorescent Folate Conjugates in an Ovarian Cancer Model.
García de Jalón E, Kleinmanns K, Fosse V, Davidson B, Bjørge L, Haug BE, McCormack E. García de Jalón E, et al. Mol Imaging Biol. 2023 Feb;25(1):144-155. doi: 10.1007/s11307-021-01685-y. Epub 2021 Dec 10. Mol Imaging Biol. 2023. PMID: 34888759 Free PMC article.
PROCEDURES: ZW800-1, ZW800-1 Forte, IRDye 800CW, ICG-OSu and an in-house synthesised Cy7 derivative were conjugated to folate through an ethylenediamine linker resulting in conjugates 1-5, respectively. The optical properties of all conjugates were determined by spectrosco …
PROCEDURES: ZW800-1, ZW800-1 Forte, IRDye 800CW, ICG-OSu and an in-house synthesised Cy7 derivative were conjugated to folate through an eth …
Anomalous structural dynamics of minimally frustrated residues in cardiac troponin C triggers hypertrophic cardiomyopathy.
Marques MA, Landim-Vieira M, Moraes AH, Sun B, Johnston JR, Dieseldorff Jones KM, Cino EA, Parvatiyar MS, Valera IC, Silva JL, Galkin VE, Chase PB, Kekenes-Huskey PM, de Oliveira GAP, Pinto JR. Marques MA, et al. Chem Sci. 2021 Apr 29;12(21):7308-7323. doi: 10.1039/d1sc01886h. Chem Sci. 2021. PMID: 34163821 Free PMC article.
Here, we report the molecular basis of a human mutation in cTnC's alphaD-helix (TNNC1-p.C84Y) that impacts conformational dynamics of the D/E central-linker and sampling of discrete states in the N-domain, favoring the "primed" state associated with Ca(2+) binding. ...
Here, we report the molecular basis of a human mutation in cTnC's alphaD-helix (TNNC1-p.C84Y) that impacts conformational dynamics of the D/ …
Inhibition of the Human Hsc70 System by Small Ligands as a Potential Anticancer Approach.
Dublang L, Underhaug J, Flydal MI, Velasco-Carneros L, Maréchal JD, Moro F, Boyano MD, Martinez A, Muga A. Dublang L, et al. Cancers (Basel). 2021 Jun 11;13(12):2936. doi: 10.3390/cancers13122936. Cancers (Basel). 2021. PMID: 34208232 Free PMC article.
Docking and molecular dynamics simulations indicate that this compound interacts with regions located in the nucleotide-binding domain and the linker of the chaperones, modulating their ATPase activity. Thus, repurposing of pinaverium bromide for cancer treatment appears a …
Docking and molecular dynamics simulations indicate that this compound interacts with regions located in the nucleotide-binding domain and t …
Novel thioamide derivatives as neutral CB1 receptor antagonists.
Boström J, Olsson RI, Tholander J, Greasley PJ, Ryberg E, Nordberg H, Hjorth S, Cheng L. Boström J, et al. Bioorg Med Chem Lett. 2010 Jan 15;20(2):479-82. doi: 10.1016/j.bmcl.2009.11.125. Epub 2009 Nov 27. Bioorg Med Chem Lett. 2010. PMID: 20005704
A novel class of cannabinoid-1 (CB1) receptor antagonists for the treatment of obesity is presented. The carboxamide linker in a set of 5,6-diaryl-pyrazine-2-amide derivatives was transformed into the corresponding thioamide, by using a one-pot synthesis. ...
A novel class of cannabinoid-1 (CB1) receptor antagonists for the treatment of obesity is presented. The carboxamide linker in a set …
Arc is a flexible modular protein capable of reversible self-oligomerization.
Myrum C, Baumann A, Bustad HJ, Flydal MI, Mariaule V, Alvira S, Cuéllar J, Haavik J, Soulé J, Valpuesta JM, Márquez JA, Martinez A, Bramham CR. Myrum C, et al. Biochem J. 2015 May 15;468(1):145-58. doi: 10.1042/BJ20141446. Biochem J. 2015. PMID: 25748042 Free PMC article.
Limited proteolysis assays and MS analysis indicate that hArc has two major domains on either side of a central more disordered linker region, consistent with in silico structure predictions. hArc's secondary structure was estimated using CD, and stability was analysed by …
Limited proteolysis assays and MS analysis indicate that hArc has two major domains on either side of a central more disordered linker …
Characterization of SGN-CD123A, A Potent CD123-Directed Antibody-Drug Conjugate for Acute Myeloid Leukemia.
Li F, Sutherland MK, Yu C, Walter RB, Westendorf L, Valliere-Douglass J, Pan L, Cronkite A, Sussman D, Klussman K, Ulrich M, Anderson ME, Stone IJ, Zeng W, Jonas M, Lewis TS, Goswami M, Wang SA, Senter PD, Law CL, Feldman EJ, Benjamin DR. Li F, et al. Mol Cancer Ther. 2018 Feb;17(2):554-564. doi: 10.1158/1535-7163.MCT-17-0742. Epub 2017 Nov 15. Mol Cancer Ther. 2018. PMID: 29142066
Here, we report the generation and preclinical characterization of SGN-CD123A, an antibody-drug conjugate using the pyrrolobenzodiazepine dimer (PBD) linker and a humanized CD123 antibody with engineered cysteines for site-specific conjugation. ...
Here, we report the generation and preclinical characterization of SGN-CD123A, an antibody-drug conjugate using the pyrrolobenzodiazepine di …
Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index.
Lyon RP, Bovee TD, Doronina SO, Burke PJ, Hunter JH, Neff-LaFord HD, Jonas M, Anderson ME, Setter JR, Senter PD. Lyon RP, et al. Nat Biotechnol. 2015 Jul;33(7):733-5. doi: 10.1038/nbt.3212. Epub 2015 Jun 15. Nat Biotechnol. 2015. PMID: 26076429
Here we show that accelerated clearance arises from ADC hydrophobicity, which can be modulated through drug-linker design. We exemplify this using hydrophilic auristatin drug linkers and PEGylated ADCs that yield uniform, high-DAR ADCs with superior in vivo performa …
Here we show that accelerated clearance arises from ADC hydrophobicity, which can be modulated through drug-linker design. We exempli …
Qualitative analysis of antibody-drug conjugates (ADCs): an experimental comparison of analytical techniques of cysteine-linked ADCs.
Källsten M , Hartmann R , Artemenko K , Lind SB , Lehmann F , Bergquist J . Källsten M , et al. Analyst. 2018 Nov 5;143(22):5487-5496. doi: 10.1039/c8an01178h. Analyst. 2018. PMID: 30289422
Antibody-drug conjugates (ADCs) are an emerging type of biotherapeutics that utilize multiple tissue-specific antibodies combined with a range of linker designs to enable the transportation and selective release of cytotoxic drugs in close proximity to tumours. ...Four dif …
Antibody-drug conjugates (ADCs) are an emerging type of biotherapeutics that utilize multiple tissue-specific antibodies combined with a ran …
An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay.
Jonas S, Christie M, Peter D, Bhandari D, Loh B, Huntzinger E, Weichenrieder O, Izaurralde E. Jonas S, et al. Nat Struct Mol Biol. 2014 Jul;21(7):599-608. doi: 10.1038/nsmb.2837. Epub 2014 Jun 1. Nat Struct Mol Biol. 2014. PMID: 24880343
The assembly unit contains a WD40 propeller connected to an adaptable linker. The propeller contacts the PAN3 C-terminal domain, whereas the linker reinforces the asymmetry of the PAN3 dimer and prevents the recruitment of a second PAN2 molecule. ...
The assembly unit contains a WD40 propeller connected to an adaptable linker. The propeller contacts the PAN3 C-terminal domain, wher …
17 results