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Page 1
Spider-venom peptides as therapeutics.
Toxins (Basel). 2010 Dec;2(12):2851-71. doi: 10.3390/toxins2122851. Epub 2010 Dec 20.
Toxins (Basel). 2010.
PMID: 22069579
Free PMC article.
Review.
Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3.
Jensen JE, Durek T, Alewood PF, Adams DJ, King GF, Rash LD.
Jensen JE, et al.
Toxicon. 2009 Jul;54(1):56-61. doi: 10.1016/j.toxicon.2009.03.014. Epub 2009 Mar 21.
Toxicon. 2009.
PMID: 19306891
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Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3.
Jensen JE, Mobli M, Brust A, Alewood PF, King GF, Rash LD.
Jensen JE, et al.
Mar Drugs. 2012 Jul;10(7):1511-1527. doi: 10.3390/md10071511. Epub 2012 Jul 16.
Mar Drugs. 2012.
PMID: 22851922
Free PMC article.
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Understanding the molecular basis of toxin promiscuity: the analgesic sea anemone peptide APETx2 interacts with acid-sensing ion channel 3 and hERG channels via overlapping pharmacophores.
Jensen JE, Cristofori-Armstrong B, Anangi R, Rosengren KJ, Lau CH, Mobli M, Brust A, Alewood PF, King GF, Rash LD.
Jensen JE, et al.
J Med Chem. 2014 Nov 13;57(21):9195-203. doi: 10.1021/jm501400p. Epub 2014 Nov 4.
J Med Chem. 2014.
PMID: 25337890
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Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor.
Halai R, Clark RJ, Nevin ST, Jensen JE, Adams DJ, Craik DJ.
Halai R, et al. Among authors: jensen je.
J Biol Chem. 2009 Jul 24;284(30):20275-84. doi: 10.1074/jbc.M109.015339. Epub 2009 May 15.
J Biol Chem. 2009.
PMID: 19447885
Free PMC article.
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