Neisseria gonorrhoeae scavenges host sialic acid for Siglec-mediated, complement-independent suppression of neutrophil activation.
Cardenas AJ, Thomas KS, Broden MW, Ferraro NJ, John CM, Pires MM, Jarvis GA, Criss AK.
Cardenas AJ, et al. Among authors: john cm.
bioRxiv [Preprint]. 2024 Jan 18:2024.01.17.576097. doi: 10.1101/2024.01.17.576097.
bioRxiv. 2024.
PMID: 38293026
Free PMC article.
Updated.
Preprint.
In the absence of complement, we found sialylated Gc expressing opacity-associated (Opa) proteins decreased the oxidative burst and granule exocytosis from primary human neutrophils. In addition, sialylated Opa+ Gc survived better than vehicle treated or deltalst Gc when c …
In the absence of complement, we found sialylated Gc expressing opacity-associated (Opa) proteins decreased the oxidative burst and g …