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Neisseria gonorrhoeae scavenges host sialic acid for Siglec-mediated, complement-independent suppression of neutrophil activation.
Cardenas AJ, Thomas KS, Broden MW, Ferraro NJ, Pires MM, John CM, Jarvis GA, Criss AK. Cardenas AJ, et al. Among authors: john cm. mBio. 2024 Apr 9:e0011924. doi: 10.1128/mbio.00119-24. Online ahead of print. mBio. 2024. PMID: 38587424 Free article.
In the absence of complement, we found sialylated Gc expressing opacity-associated (Opa) proteins decreased the oxidative burst and granule exocytosis from primary human neutrophils. In addition, sialylated Opa+ Gc survived better than vehicle treated or deltalst Gc when c …
In the absence of complement, we found sialylated Gc expressing opacity-associated (Opa) proteins decreased the oxidative burst and g …
Neisseria gonorrhoeae scavenges host sialic acid for Siglec-mediated, complement-independent suppression of neutrophil activation.
Cardenas AJ, Thomas KS, Broden MW, Ferraro NJ, John CM, Pires MM, Jarvis GA, Criss AK. Cardenas AJ, et al. Among authors: john cm. bioRxiv [Preprint]. 2024 Jan 18:2024.01.17.576097. doi: 10.1101/2024.01.17.576097. bioRxiv. 2024. PMID: 38293026 Free PMC article. Updated. Preprint.
In the absence of complement, we found sialylated Gc expressing opacity-associated (Opa) proteins decreased the oxidative burst and granule exocytosis from primary human neutrophils. In addition, sialylated Opa+ Gc survived better than vehicle treated or deltalst Gc when c …
In the absence of complement, we found sialylated Gc expressing opacity-associated (Opa) proteins decreased the oxidative burst and g …
Preliminary study on overproduction of reactive oxygen species by neutrophils in diabetes mellitus.
Ridzuan N, John CM, Sandrasaigaran P, Maqbool M, Liew LC, Lim J, Ramasamy R. Ridzuan N, et al. Among authors: john cm. World J Diabetes. 2016 Jul 10;7(13):271-8. doi: 10.4239/wjd.v7.i13.271. World J Diabetes. 2016. PMID: 27433296 Free PMC article.
METHODS: Blood samples from type 2 diabetes mellitus (DM) patients and volunteers (controls) were subjected to neutrophil isolation and the assessment of neutrophil oxidative burst using chemiluminescence assay. Neutrophils were activated by using phorbol myristate acetate …
METHODS: Blood samples from type 2 diabetes mellitus (DM) patients and volunteers (controls) were subjected to neutrophil isolation and the …
Immunomodulatory activity of polyphenols derived from Cassia auriculata flowers in aged rats.
John CM, Sandrasaigaran P, Tong CK, Adam A, Ramasamy R. John CM, et al. Cell Immunol. 2011;271(2):474-9. doi: 10.1016/j.cellimm.2011.08.017. Epub 2011 Aug 28. Cell Immunol. 2011. PMID: 21924708
In terms of innate immune cell activity, CA polyphenol supplementation reduced the oxidative burst activity of neutrophils in response to PMA and Escherichia coli activation. ...
In terms of innate immune cell activity, CA polyphenol supplementation reduced the oxidative burst activity of neutrophils in respons …
Enhanced CD4+CD25+ regulatory T cells with splenic proliferation and protection against oxidative stress by nicotinamide in gestational diabetes.
John CM, Ramasamy R, Al Naqeeb G, Dhiab Al-Nuaimi AH, Adam A. John CM, et al. Curr Med Chem. 2012 Aug 16. Online ahead of print. Curr Med Chem. 2012. PMID: 22934758
The highest dose enhanced expression of Tregs and increased splenocytes proliferation in both resting and lipopolysaccharide (LPS)-stimulated cells. Oxidative burst activity of neutrophils in response to phorbol myristate acetate (PMA), N-formyl-methionyl-leucyl-phenylalan …
The highest dose enhanced expression of Tregs and increased splenocytes proliferation in both resting and lipopolysaccharide (LPS)-stimulate …
Nicotinamide supplementation protects gestational diabetic rats by reducing oxidative stress and enhancing immune responses.
John CM, Ramasamy R, Al Naqeeb G, Al-Nuaimi AH, Adam A. John CM, et al. Curr Med Chem. 2012;19(30):5181-6. doi: 10.2174/092986712803530449. Curr Med Chem. 2012. PMID: 23237188
The same doses of nicotinamide upregulated mRNA expressions of SOD and CAT genes in liver but reduced the oxidative burst activity of neutrophils in response to phorbol myristate acetate (PMA), N-formyl-methionyl-leucyl-phenylalanine (FMLP) or E. coli activation. ...
The same doses of nicotinamide upregulated mRNA expressions of SOD and CAT genes in liver but reduced the oxidative burst activity of …