John J. Alam - Search Results

Year	Number of Results
2003	1
2012	1
2015	1
2020	2
2021	1
2022	2
2023	3
2024	0

1

P38α MAPK Signaling-A Robust Therapeutic Target for Rab5-Mediated Neurodegenerative Disease.

Germann UA, Alam JJ. Germann UA, et al. Among authors: alam jj. Int J Mol Sci. 2020 Jul 31;21(15):5485. doi: 10.3390/ijms21155485. Int J Mol Sci. 2020. PMID: 32751991 Free PMC article. Review.

2

Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration.

Jiang Y, Alam JJ, Gomperts SN, Maruff P, Lemstra AW, Germann UA, Stavrides PH, Darji S, Malampati S, Peddy J, Bleiwas C, Pawlik M, Pensalfini A, Yang DS, Subbanna S, Basavarajappa BS, Smiley JF, Gardner A, Blackburn K, Chu HM, Prins ND, Teunissen CE, Harrison JE, Scheltens P, Nixon RA. Jiang Y, et al. Among authors: alam jj. Nat Commun. 2022 Sep 21;13(1):5308. doi: 10.1038/s41467-022-32944-3. Nat Commun. 2022. PMID: 36130946 Free PMC article. Clinical Trial.

3

Apoptosis: target for novel drugs.

Alam JJ. Alam JJ. Trends Biotechnol. 2003 Nov;21(11):479-83. doi: 10.1016/j.tibtech.2003.08.006. Trends Biotechnol. 2003. PMID: 14573360 Review.

4

Association of Plasma Phosphorylated Tau With the Response to Neflamapimod Treatment in Patients With Dementia With Lewy Bodies.

Alam JJ, Maruff P, Doctrow SR, Chu HM, Conway J, Gomperts SN, Teunissen C. Alam JJ, et al. Neurology. 2023 Oct 24;101(17):e1708-e1717. doi: 10.1212/WNL.0000000000207755. Epub 2023 Sep 1. Neurology. 2023. PMID: 37657939 Free PMC article. Clinical Trial.

5

Disease-modifying pharmacological approaches to correcting basal forebrain cholinergic neuronal (BFCN) dysfunction and degeneration.

Alam JJ, Nixon RA. Alam JJ, et al. Neuropsychopharmacology. 2022 Jan;47(1):405-406. doi: 10.1038/s41386-021-01135-x. Neuropsychopharmacology. 2022. PMID: 34389810 Free PMC article. No abstract available.

6

Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come.

Alam JJ, Nixon RA. Alam JJ, et al. Mol Neurodegener. 2023 Oct 4;18(1):74. doi: 10.1186/s13024-023-00663-y. Mol Neurodegener. 2023. PMID: 37794391 Free PMC article. No abstract available.

7

Correction: Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come.

Alam JJ, Nixon RA. Alam JJ, et al. Mol Neurodegener. 2023 Nov 9;18(1):81. doi: 10.1186/s13024-023-00678-5. Mol Neurodegener. 2023. PMID: 37946303 Free PMC article. No abstract available.

8

A phase 2 double-blind placebo-controlled 24-week treatment clinical study of the p38 alpha kinase inhibitor neflamapimod in mild Alzheimer's disease.

Prins ND, Harrison JE, Chu HM, Blackburn K, Alam JJ, Scheltens P; REVERSE-SD Study Investigators. Prins ND, et al. Among authors: alam jj. Alzheimers Res Ther. 2021 May 27;13(1):106. doi: 10.1186/s13195-021-00843-2. Alzheimers Res Ther. 2021. PMID: 34044875 Free PMC article. Clinical Trial.

9

Continuous administration of a p38α inhibitor during the subacute phase after transient ischemia-induced stroke in the rat promotes dose-dependent functional recovery accompanied by increase in brain BDNF protein level.

Alam JJ, Krakovsky M, Germann U, Levy A. Alam JJ, et al. PLoS One. 2020 Dec 4;15(12):e0233073. doi: 10.1371/journal.pone.0233073. eCollection 2020. PLoS One. 2020. PMID: 33275615 Free PMC article.

10

Selective Brain-Targeted Antagonism of p38 MAPKα Reduces Hippocampal IL-1β Levels and Improves Morris Water Maze Performance in Aged Rats.

Alam JJ. Alam JJ. J Alzheimers Dis. 2015;48(1):219-27. doi: 10.3233/JAD-150277. J Alzheimers Dis. 2015. PMID: 26401942 Free PMC article.

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