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A heretical view: rather than a solely placental protective function, placental 11β hydroxysteroid dehydrogenase 2 also provides substrate for fetal peripheral cortisol synthesis in obese pregnant ewes.
Ghnenis AB, Odhiambo JF, Smith AM, Pankey CL, Nathanielsz PW, Ford SP. Ghnenis AB, et al. Among authors: odhiambo jf. J Dev Orig Health Dis. 2021 Feb;12(1):94-100. doi: 10.1017/S2040174420000112. Epub 2020 Mar 10. J Dev Orig Health Dis. 2021. PMID: 32151296
Diet reduction to requirements in obese/overfed ewes from early gestation prevents glucose/insulin dysregulation and returns fetal adiposity and organ development to control levels.
Tuersunjiang N, Odhiambo JF, Long NM, Shasa DR, Nathanielsz PW, Ford SP. Tuersunjiang N, et al. Among authors: odhiambo jf. Am J Physiol Endocrinol Metab. 2013 Oct 1;305(7):E868-78. doi: 10.1152/ajpendo.00117.2013. Epub 2013 Aug 6. Am J Physiol Endocrinol Metab. 2013. PMID: 23921140 Free PMC article.