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Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: A hybrid clinical-preclinical study.
de Castro Silva I, Bianchi A, Deshpande NU, Sharma P, Mehra S, Garrido VT, Saigh SJ, England J, Hosein PJ, Kwon D, Merchant NB, Datta J. de Castro Silva I, et al. Elife. 2022 Sep 15;11:e78921. doi: 10.7554/eLife.78921. Elife. 2022. PMID: 36107485 Free PMC article. Clinical Trial.
RESULTS: In 94 PDAC patients undergoing NAC (median:4 months), pre-chemotherapy NLR (p<0.001) and deltaNLR attenuation during NAC (p=0.002) were independently associated with partial/complete pathologic response. ...FUNDING: Supported by KL2 career development gr …
RESULTS: In 94 PDAC patients undergoing NAC (median:4 months), pre-chemotherapy NLR (p<0.001) and deltaNLR attenuation during NAC …
Impact of centre volume, surgeon volume, surgeon experience and geographic location on reoperation after intramedullary nailing of tibial shaft fractures.
Swiontkowski M, Teague D, Sprague S, Bzovsky S, Heels-Ansdell D, Bhandari M, Schemitsch EH, Sanders DW, Tornetta P, Walter SD; SPRINT Investigators. Swiontkowski M, et al. Can J Surg. 2021 Jul 5;64(4):E371-E376. doi: 10.1503/cjs.004020. Can J Surg. 2021. PMID: 34222771 Free PMC article. Clinical Trial.
RESULTS: There were no significant differences in the odds of reoperation between high- and low-volume centres (p = 0.9). Overall, surgeon volume significantly affected the odds of reoperation (p = 0.03). ...
RESULTS: There were no significant differences in the odds of reoperation between high- and low-volume centres (p = 0.9). Overall, su …
The within-match patterns of locomotor efficiency during professional soccer match play: Implications for injury risk?
Barrett S, Midgley A, Reeves M, Joel T, Franklin E, Heyworth R, Garrett A, Lovell R. Barrett S, et al. J Sci Med Sport. 2016 Oct;19(10):810-5. doi: 10.1016/j.jsams.2015.12.514. Epub 2015 Dec 29. J Sci Med Sport. 2016. PMID: 26787341
RESULTS: PLVM, PLAP, APML, APv and TDC reduced after the initial 15-min match period (p=0.001; eta(2)=0.22-0.43, large effects). PL:TDC increased in the last 15min of each half (p=0.001; eta(2)=0.25, large effect). The variance in PLVM during soccer match-play was e …
RESULTS: PLVM, PLAP, APML, APv and TDC reduced after the initial 15-min match period (p=0.001; eta(2)=0.22-0.43, large effects). PL:T …
Childhood Cancer Survivor Study participants' perceptions and understanding of the Affordable Care Act.
Park ER, Kirchhoff AC, Perez GK, Leisenring W, Weissman JS, Donelan K, Mertens AC, Reschovsky JD, Armstrong GT, Robison LL, Franklin M, Hyland KA, Diller LR, Recklitis CJ, Kuhlthau KA. Park ER, et al. J Clin Oncol. 2015 Mar 1;33(7):764-72. doi: 10.1200/JCO.2014.58.0993. Epub 2015 Feb 2. J Clin Oncol. 2015. PMID: 25646189 Free PMC article.

Survivors were more likely than siblings to deem primary care physician coverage and choice, protections from costs due to pre-existing conditions, and no start-up period as "very important" (P < .05 for all). Only 27.3% of survivors and 26.2% of siblings reported famil

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Survivors were more likely than siblings to deem primary care physician coverage and choice, protections from costs due to pre-existing cond …
Non-infectious rhinitis is more strongly associated with early-rather than late-onset of COPD: data from the European Community Respiratory Health Survey (ECRHS).
Bergqvist J, Andersson A, Schiöler L, Olin AC, Murgia N, Bove M, Janson C, Abramson MJ, Leynaert B, Nowak D, Franklin KA, Pin I, Storaas T, Schlünssen V, Heinrich J, Hellgren J. Bergqvist J, et al. Eur Arch Otorhinolaryngol. 2020 May;277(5):1353-1359. doi: 10.1007/s00405-020-05837-8. Epub 2020 Feb 11. Eur Arch Otorhinolaryngol. 2020. PMID: 32048027 Free PMC article.
RESULTS: Non-infectious rhinitis was significantly more prevalent in subjects with COPD compared with no COPD (48.9% vs 37.1%, p < 0.001) in ECRHS II (mean age 43) but not in ECHRS III (mean age 54). ...
RESULTS: Non-infectious rhinitis was significantly more prevalent in subjects with COPD compared with no COPD (48.9% vs 37.1%, p < …