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Page 1
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly.
McNeil JJ, Wolfe R, Woods RL, Tonkin AM, Donnan GA, Nelson MR, Reid CM, Lockery JE, Kirpach B, Storey E, Shah RC, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Johnston CI, Ryan J, Radziszewska B, Jelinek M, Malik M, Eaton CB, Brauer D, Cloud G, Wood EM, Mahady SE, Satterfield S, Grimm R, Murray AM; ASPREE Investigator Group. McNeil JJ, et al. N Engl J Med. 2018 Oct 18;379(16):1509-1518. doi: 10.1056/NEJMoa1805819. Epub 2018 Sep 16. N Engl J Med. 2018. PMID: 30221597 Free PMC article. Clinical Trial.
The rate of major hemorrhage was 8.6 events per 1000 person-years and 6.2 events per 1000 person-years, respectively (hazard ratio, 1.38; 95% CI, 1.18 to 1.62; P<0.001). CONCLUSIONS: The use of low-dose aspirin as a primary prevention strategy in older adults resulted i …
The rate of major hemorrhage was 8.6 events per 1000 person-years and 6.2 events per 1000 person-years, respectively (hazard ratio, 1.38; 95 …
Effect of Aspirin on All-Cause Mortality in the Healthy Elderly.
McNeil JJ, Nelson MR, Woods RL, Lockery JE, Wolfe R, Reid CM, Kirpach B, Shah RC, Ives DG, Storey E, Ryan J, Tonkin AM, Newman AB, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Radziszewska B, Grimm R, Murray AM; ASPREE Investigator Group. McNeil JJ, et al. N Engl J Med. 2018 Oct 18;379(16):1519-1528. doi: 10.1056/NEJMoa1803955. Epub 2018 Sep 16. N Engl J Med. 2018. PMID: 30221595 Free PMC article. Clinical Trial.
Invisible Allies: Thanking Our Reviewers.
[No authors listed] [No authors listed] J Am Acad Child Adolesc Psychiatry. 2018 Dec;57(12):989-992. doi: 10.1016/j.jaac.2018.10.003. J Am Acad Child Adolesc Psychiatry. 2018. PMID: 30522747
Frank, James F. Leckman, Christel Middeldorp, Lawrence Scahill, Joel Stoddard, Argyris Stringaris, Peter Szatmari, and Bonnie T. ...Biel, Alice Charach, Laura M. Prager, and S. Evelyn Stewart). We are also appreciative that Michael H. Bloch will continue his service …
Frank, James F. Leckman, Christel Middeldorp, Lawrence Scahill, Joel Stoddard, Argyris Stringaris, Peter Szatmari, and Bonnie T. ...B …
Effect of Aspirin on Disability-free Survival in the Healthy Elderly.
McNeil JJ, Woods RL, Nelson MR, Reid CM, Kirpach B, Wolfe R, Storey E, Shah RC, Lockery JE, Tonkin AM, Newman AB, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Ryan J, Radziszewska B, Grimm R, Murray AM; ASPREE Investigator Group. McNeil JJ, et al. N Engl J Med. 2018 Oct 18;379(16):1499-1508. doi: 10.1056/NEJMoa1800722. Epub 2018 Sep 16. N Engl J Med. 2018. PMID: 30221596 Free PMC article. Clinical Trial.
The rate of the composite of death, dementia, or persistent physical disability was 21.5 events per 1000 person-years in the aspirin group and 21.2 per 1000 person-years in the placebo group (hazard ratio, 1.01; 95% confidence interval [CI], 0.92 to 1.11; P=0.79). The rate …
The rate of the composite of death, dementia, or persistent physical disability was 21.5 events per 1000 person-years in the aspirin group a …
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection.
GlobalSurg Collaborative. GlobalSurg Collaborative. BJS Open. 2019 Feb 28;3(3):403-414. doi: 10.1002/bjs5.50138. eCollection 2019 Jun. BJS Open. 2019. PMID: 31891112 Free PMC article.

There was a higher proportion of patients with perforated disease (57.5, 40.9 and 35.4 per cent; P < 0.001) and subsequent use of end colostomy (52.2, 24.8 and 18.9 per cent; P < 0.001) in low- compared with middle- and high-HDI settings. The association with

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There was a higher proportion of patients with perforated disease (57.5, 40.9 and 35.4 per cent; P < 0.001) and subsequent use of

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Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy.
GlobalSurg Collaborative. GlobalSurg Collaborative. Br J Surg. 2019 Jan;106(2):e103-e112. doi: 10.1002/bjs.11051. Br J Surg. 2019. PMID: 30620059 Free PMC article.
After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (O …
After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human De …
Progression of Fatty Liver Disease in Children Receiving Standard of Care Lifestyle Advice.
Xanthakos SA, Lavine JE, Yates KP, Schwimmer JB, Molleston JP, Rosenthal P, Murray KF, Vos MB, Jain AK, Scheimann AO, Miloh T, Fishbein M, Behling CA, Brunt EM, Sanyal AJ, Tonascia J; NASH Clinical Research Network. Xanthakos SA, et al. Gastroenterology. 2020 Nov;159(5):1731-1751.e10. doi: 10.1053/j.gastro.2020.07.034. Epub 2020 Jul 23. Gastroenterology. 2020. PMID: 32712103 Free PMC article.
Any progression to definite NASH and/or in fibrosis was associated with adolescent age, and higher waist circumference, levels of alanine or aspartate aminotransferase, total and low-density lipoprotein cholesterol at baseline (<0.05), and over follow-up time, with increasing …
Any progression to definite NASH and/or in fibrosis was associated with adolescent age, and higher waist circumference, levels of alanine or …
Preoperative risk factors for conversion from laparoscopic to open cholecystectomy: a validated risk score derived from a prospective U.K. database of 8820 patients.
Sutcliffe RP, Hollyman M, Hodson J, Bonney G, Vohra RS, Griffiths EA; CholeS study group, West Midlands Research Collaborative. Sutcliffe RP, et al. HPB (Oxford). 2016 Nov;18(11):922-928. doi: 10.1016/j.hpb.2016.07.015. Epub 2016 Aug 31. HPB (Oxford). 2016. PMID: 27591176 Free PMC article.

The risk score was derived from six significant predictors: age (p = 0.005), sex (p < 0.001), indication for surgery (p < 0.001), ASA (p < 0.001), thick-walled gallbladder (p = 0.040) and CBD diameter (p = 0.004). Testing the sco

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The risk score was derived from six significant predictors: age (p = 0.005), sex (p < 0.001), indication for surgery (p

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Predicting the difficult laparoscopic cholecystectomy: development and validation of a pre-operative risk score using an objective operative difficulty grading system.
Nassar AHM, Hodson J, Ng HJ, Vohra RS, Katbeh T, Zino S, Griffiths EA; CholeS Study Group, West Midlands Research Collaborative. Nassar AHM, et al. Surg Endosc. 2020 Oct;34(10):4549-4561. doi: 10.1007/s00464-019-07244-5. Epub 2019 Nov 15. Surg Endosc. 2020. PMID: 31732855
A risk score based on these factors returned an area under the ROC curve of 0.789 (95% CI 0.773-0.806, p < 0.001) on external validation, with 11.0% versus 80.0% of patients classified as low versus high risk having difficult surgeries. ...

A risk score based on these factors returned an area under the ROC curve of 0.789 (95% CI 0.773-0.806, p < 0.001) on external vali

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The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy.
Bharamgoudar R, Sonsale A, Hodson J, Griffiths E; CholeS Study Group, West Midlands Research Collaborative. Bharamgoudar R, et al. Surg Endosc. 2018 Jul;32(7):3149-3157. doi: 10.1007/s00464-018-6030-6. Epub 2018 Jan 16. Surg Endosc. 2018. PMID: 29340820 Free PMC article.
This returned an area under the ROC curve of 0.708 (SE = 0.013, p < 0.001), with the proportions of operations lasting > 90 min increasing more than eightfold from 5.1 to 41.8% in the extremes of the score. ...

This returned an area under the ROC curve of 0.708 (SE = 0.013, p < 0.001), with the proportions of operations lasting > 90 min

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12 results