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Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer (KEYNOTE-355): a randomised, placebo-controlled, double-blind, phase 3 clinical trial.
Lancet. 2020 Dec 5;396(10265):1817-1828. doi: 10.1016/S0140-6736(20)32531-9.
Lancet. 2020.
PMID: 33278935
Clinical Trial.
Among patients with CPS of 10 or more, median progression-free survival was 9.7 months with pembrolizumab-chemotherapy and 5.6 months with placebo-chemotherapy (hazard ratio [HR] for progression or death, 0.65, 95% CI 0.49-0.86; one-sided p=0.0012 [primary objective met]). …
Among patients with CPS of 10 or more, median progression-free survival was 9.7 months with pembrolizumab-chemotherapy and 5.6 months with p …
Conflict of Interest Disclosures.
[No authors listed]
[No authors listed]
Global Spine J. 2023 May;13(2_suppl):568S-591S. doi: 10.1177/21925682231173597.
Global Spine J. 2023.
PMID: 37222100
Free PMC article.
No abstract available.
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Easing of suffering in children with cancer at the end of life: is care changing?
Wolfe J, Hammel JF, Edwards KE, Duncan J, Comeau M, Breyer J, Aldridge SA, Grier HE, Berde C, Dussel V, Weeks JC.
Wolfe J, et al.
J Clin Oncol. 2008 Apr 1;26(10):1717-23. doi: 10.1200/JCO.2007.14.0277.
J Clin Oncol. 2008.
PMID: 18375901
Do-not-resuscitate orders were also documented earlier (18 v 12 days; P = .031). Deaths in the intensive care unit or other hospitals decreased significantly (RD, 16%; P = .024). Parents reported less child suffering from pain (RD, 19%; P = .018) and dyspnea …
Do-not-resuscitate orders were also documented earlier (18 v 12 days; P = .031). Deaths in the intensive care unit or other hospitals …
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Understanding of prognosis among parents of children who died of cancer: impact on treatment goals and integration of palliative care.
Wolfe J, Klar N, Grier HE, Duncan J, Salem-Schatz S, Emanuel EJ, Weeks JC.
Wolfe J, et al.
JAMA. 2000 Nov 15;284(19):2469-75. doi: 10.1001/jama.284.19.2469.
JAMA. 2000.
PMID: 11074776
Among children who died of progressive disease, the group characterized by earlier recognition of this prognosis by both parents and physicians had earlier discussions of hospice care (odds ratio [OR], 1.03; 95% confidence interval [CI], 1.01-1.06; P =.01), better parental …
Among children who died of progressive disease, the group characterized by earlier recognition of this prognosis by both parents and physici …
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