MBOAT7 rs641738 (C>T) is associated with NAFLD progression in men and decreased ASCVD risk in elder Chinese population

Xiaoyi Xu; Hangfei Xu; Xiaohui Liu; Shuang Zhang; Zhenhuan Cao; Lixia Qiu; Xiaofei Du; Yali Liu; Gang Wang; Li Zhang; Yang Zhang; Jing Zhang

doi:10.3389/fendo.2023.1199429

MBOAT7 rs641738 (C>T) is associated with NAFLD progression in men and decreased ASCVD risk in elder Chinese population

Front Endocrinol (Lausanne). 2023 Jun 22:14:1199429. doi: 10.3389/fendo.2023.1199429. eCollection 2023.

Authors

Xiaoyi Xu^{1

2}, Hangfei Xu^{1

2}, Xiaohui Liu¹, Shuang Zhang^{1

3}, Zhenhuan Cao¹, Lixia Qiu¹, Xiaofei Du¹, Yali Liu¹, Gang Wang³, Li Zhang³, Yang Zhang^{1

2}, Jing Zhang¹

Affiliations

¹ The Third Unit, The Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
² Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
³ Menkuang Hospital, Beijing Jingmei Group General Hospital, Beijing, China.

Abstract

Background and aim: The MBOAT7 rs641738 (C>T) variant has demonstrated an association with non-alcoholic fatty liver disease (NAFLD) in both adult and pediatric patients, while few studies have been conducted in elderly populations. Hence, a case-control study was undertaken to assess their correlation in elderly residents in a Beijing community.

Materials and methods: A total of 1,287 participants were included. Medical history, abdominal ultrasound, and laboratory tests were recorded. Liver fat content and fibrosis stage were detected by Fibroscan. Genotyping of genomic DNA was performed using the 96.96 genotyping integrated fluidics circuit.

Results: Of the recruited subjects, 638 subjects (56.60%) had NAFLD, and 398 subjects (35.28%) had atherosclerotic cardiovascular disease (ASCVD). T allele carriage was associated with higher ALT (p=0.005) and significant fibrosis in male NAFLD patients (p=0.005) compared to CC genotype. TT genotype was associated with reduced risk of metabolic syndrome (OR=0.589, 95%CI: 0.114-0.683, p=0.005) and type 2 diabetes (OR=0.804, 95%CI: 0.277-0.296, p=0.048) in NAFLD population when compared to the CC genotype. In addition, TT genotype was also associated with reduced risk of ASCVD (OR=0.570, 95%CI:0.340-0.953, p=0.032) and less obesity (OR=0.545, 95%CI: 0.346-0.856, p=0.008) in the whole population.

Conclusion: MBOAT7 rs641738 (C>T) variant was associated with fibrosis in male NAFLD patients. The variant also reduced risk of metabolic traits and type 2 diabetes in NAFLD and ASCVD risk in Chinese elders.

Keywords: MBOAT7; atherosclerotic cardiovascular disease; fibrosis; non-alcoholic fatty liver disease; single-nucleotide polymorphism.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acyltransferases* / genetics
Aged
Case-Control Studies
Diabetes Mellitus, Type 2* / complications
Diabetes Mellitus, Type 2* / epidemiology
Diabetes Mellitus, Type 2* / genetics
East Asian People
Fibrosis
Genetic Predisposition to Disease
Humans
Male
Membrane Proteins* / genetics
Non-alcoholic Fatty Liver Disease* / complications
Non-alcoholic Fatty Liver Disease* / epidemiology
Non-alcoholic Fatty Liver Disease* / genetics
Polymorphism, Single Nucleotide

Substances

Acyltransferases
MBOAT7 protein, human
Membrane Proteins

Grants and funding

This work was supported by grants from the National Natural Science Foundation of China (82070627), Beijing Municipal Natural Science Foundation (7222090), the Beijing Municipal Institute of Public Medical Research Development and Reform Pilot Project (2021-10), the Capitals’s Funds for Health Improvement and Research (2022-2Z-2187), and the Scientific research project of Beijing Youan Hospital CCMU, 2021 (YNKTQN 2021015) and Beijing Municipal Administration of Hospitals Incubating Program (PX2023061).