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Exploring protein hotspots by optimized fragment pharmacophores.
Bajusz D, Wade WS, Satała G, Bojarski AJ, Ilaš J, Ebner J, Grebien F, Papp H, Jakab F, Douangamath A, Fearon D, von Delft F, Schuller M, Ahel I, Wakefield A, Vajda S, Gerencsér J, Pallai P, Keserű GM. Bajusz D, et al. Among authors: ebner j. Nat Commun. 2021 May 27;12(1):3201. doi: 10.1038/s41467-021-23443-y. Nat Commun. 2021. PMID: 34045440 Free PMC article.
MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.
Skucha A, Ebner J, Schmöllerl J, Roth M, Eder T, César-Razquin A, Stukalov A, Vittori S, Muhar M, Lu B, Aichinger M, Jude J, Müller AC, Győrffy B, Vakoc CR, Valent P, Bennett KL, Zuber J, Superti-Furga G, Grebien F. Skucha A, et al. Among authors: ebner j. Nat Commun. 2018 May 18;9(1):1983. doi: 10.1038/s41467-018-04329-y. Nat Commun. 2018. PMID: 29777171 Free PMC article.
SETD2 in MLL-rearranged leukemia - a complex case.
Skucha A, Ebner J, Grebien F. Skucha A, et al. Among authors: ebner j. Mol Cell Oncol. 2018 Aug 13;5(4):e1503492. doi: 10.1080/23723556.2018.1503492. eCollection 2018. Mol Cell Oncol. 2018. PMID: 30250934 Free PMC article.
CDK6 is an essential direct target of NUP98 fusion proteins in acute myeloid leukemia.
Schmoellerl J, Barbosa IAM, Eder T, Brandstoetter T, Schmidt L, Maurer B, Troester S, Pham HTT, Sagarajit M, Ebner J, Manhart G, Aslan E, Terlecki-Zaniewicz S, Van der Veen C, Hoermann G, Duployez N, Petit A, Lapillonne H, Puissant A, Itzykson R, Moriggl R, Heuser M, Meisel R, Valent P, Sexl V, Zuber J, Grebien F. Schmoellerl J, et al. Among authors: ebner j. Blood. 2020 Jul 23;136(4):387-400. doi: 10.1182/blood.2019003267. Blood. 2020. PMID: 32344427 Free PMC article.