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Page 1
Structure-based design of bacterial nitric oxide synthase inhibitors.
Holden JK, Kang S, Hollingsworth SA, Li H, Lim N, Chen S, Huang H, Xue F, Tang W, Silverman RB, Poulos TL. Holden JK, et al. J Med Chem. 2015 Jan 22;58(2):994-1004. doi: 10.1021/jm501723p. Epub 2015 Jan 6. J Med Chem. 2015. PMID: 25522110 Free PMC article.
Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase.
Holden JK, Dejam D, Lewis MC, Huang H, Kang S, Jing Q, Xue F, Silverman RB, Poulos TL. Holden JK, et al. Biochemistry. 2015 Jul 7;54(26):4075-82. doi: 10.1021/acs.biochem.5b00431. Epub 2015 Jun 23. Biochemistry. 2015. PMID: 26062720 Free PMC article.
Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair.
Perez-Bermejo JA, Efagene O, Matern WM, Holden JK, Kabir S, Chew GM, Andreoletti G, Catton E, Ennis CL, Garcia A, Gerstenberg TL, Hill KA, Jain A, Krassovsky K, Lalisan CD, Lord D, Quejarro BJ, Sales-Lee J, Shah M, Silva BJ, Skowronski J, Strukov YG, Thomas J, Veraz M, Vijay T, Wallace KA, Yuan Y, Grogan JL, Wienert B, Lahiri P, Treusch S, Dever DP, Soros VB, Partridge JR, Seim KL. Perez-Bermejo JA, et al. Among authors: holden jk. Nat Commun. 2024 Mar 23;15(1):2625. doi: 10.1038/s41467-024-46816-5. Nat Commun. 2024. PMID: 38521763 Free PMC article.
Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling.
Holden JK, Crawford JJ, Noland CL, Schmidt S, Zbieg JR, Lacap JA, Zang R, Miller GM, Zhang Y, Beroza P, Reja R, Lee W, Tom JYK, Fong R, Steffek M, Clausen S, Hagenbeek TJ, Hu T, Zhou Z, Shen HC, Cunningham CN. Holden JK, et al. Cell Rep. 2020 Jun 23;31(12):107809. doi: 10.1016/j.celrep.2020.107809. Cell Rep. 2020. PMID: 32579935 Free article.
13 results