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Year Number of Results
2013 1
2015 1
2016 1
2018 1
2019 1
2020 3
2021 4
2022 2
2023 1
2024 1

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16 results

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Page 1
An inhibitor of oxidative phosphorylation exploits cancer vulnerability.
Molina JR, Sun Y, Protopopova M, Gera S, Bandi M, Bristow C, McAfoos T, Morlacchi P, Ackroyd J, Agip AA, Al-Atrash G, Asara J, Bardenhagen J, Carrillo CC, Carroll C, Chang E, Ciurea S, Cross JB, Czako B, Deem A, Daver N, de Groot JF, Dong JW, Feng N, Gao G, Gay J, Do MG, Greer J, Giuliani V, Han J, Han L, Henry VK, Hirst J, Huang S, Jiang Y, Kang Z, Khor T, Konoplev S, Lin YH, Liu G, Lodi A, Lofton T, Ma H, Mahendra M, Matre P, Mullinax R, Peoples M, Petrocchi A, Rodriguez-Canale J, Serreli R, Shi T, Smith M, Tabe Y, Theroff J, Tiziani S, Xu Q, Zhang Q, Muller F, DePinho RA, Toniatti C, Draetta GF, Heffernan TP, Konopleva M, Jones P, Di Francesco ME, Marszalek JR. Molina JR, et al. Among authors: ackroyd j. Nat Med. 2018 Jul;24(7):1036-1046. doi: 10.1038/s41591-018-0052-4. Epub 2018 Jun 11. Nat Med. 2018. PMID: 29892070
Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity.
Awad D, Cao PHA, Pulliam TL, Spradlin M, Subramani E, Tellman TV, Ribeiro CF, Muzzioli R, Jewell BE, Pakula H, Ackroyd JJ, Murray MM, Han JJ, Leng M, Jain A, Piyarathna B, Liu J, Song X, Zhang J, Klekers AR, Drake JM, Ittmann MM, Coarfa C, Piwnica-Worms D, Farach-Carson MC, Loda M, Eberlin LS, Frigo DE. Awad D, et al. Among authors: ackroyd jj. Cancer Res. 2024 Mar 4;84(5):703-724. doi: 10.1158/0008-5472.CAN-23-0555. Cancer Res. 2024. PMID: 38038968
Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine.
Barekatain Y, Ackroyd JJ, Yan VC, Khadka S, Wang L, Chen KC, Poral AH, Tran T, Georgiou DK, Arthur K, Lin YH, Satani N, Ballato ES, Behr EI, deCarvalho AC, Verhaak RGW, de Groot J, Huse JT, Asara JM, Kalluri R, Muller FL. Barekatain Y, et al. Among authors: ackroyd jj. Nat Commun. 2021 Jul 9;12(1):4228. doi: 10.1038/s41467-021-24240-3. Nat Commun. 2021. PMID: 34244484 Free PMC article.
Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism.
Khadka S, Lin YH, Ackroyd J, Chen YA, Sheng Y, Qian W, Guo S, Chen Y, Behr E, Barekatain Y, Uddin N, Arthur K, Yan V, Hsu WH, Chang Q, Poral A, Tran T, Chaurasia S, Georgiou DK, Asara JM, Barthel FP, Millward SW, DePinho RA, Muller FL. Khadka S, et al. Among authors: ackroyd j. bioRxiv [Preprint]. 2023 Oct 19:2023.05.07.539744. doi: 10.1101/2023.05.07.539744. bioRxiv. 2023. PMID: 37214825 Free PMC article. Preprint.
Pharmacokinetics of Orally Administered GS-441524 in Dogs.
Yan VC, Pham CD, Yan MJ, Yan AJ, Khadka S, Arthur K, Ackroyd JJ, Georgiou DK, Roon LE, Bushman LR, Anderson PL, Li C, Muller FL. Yan VC, et al. Among authors: ackroyd jj. bioRxiv [Preprint]. 2021 May 31:2021.02.04.429674. doi: 10.1101/2021.02.04.429674. bioRxiv. 2021. PMID: 34100016 Free PMC article. Preprint.
Prodrugs of a 1-Hydroxy-2-oxopiperidin-3-yl Phosphonate Enolase Inhibitor for the Treatment of ENO1-Deleted Cancers.
Yan VC, Pham CD, Ballato ES, Yang KL, Arthur K, Khadka S, Barekatain Y, Shrestha P, Tran T, Poral AH, Washington M, Raghavan S, Czako B, Pisaneschi F, Lin YH, Satani N, Hammoudi N, Ackroyd JJ, Georgiou DK, Millward SW, Muller FL. Yan VC, et al. Among authors: ackroyd jj. J Med Chem. 2022 Oct 27;65(20):13813-13832. doi: 10.1021/acs.jmedchem.2c01039. Epub 2022 Oct 17. J Med Chem. 2022. PMID: 36251833 Free PMC article.
An enolase inhibitor for the targeted treatment of ENO1-deleted cancers.
Lin YH, Satani N, Hammoudi N, Yan VC, Barekatain Y, Khadka S, Ackroyd JJ, Georgiou DK, Pham CD, Arthur K, Maxwell D, Peng Z, Leonard PG, Czako B, Pisaneschi F, Mandal P, Sun Y, Zielinski R, Pando SC, Wang X, Tran T, Xu Q, Wu Q, Jiang Y, Kang Z, Asara JM, Priebe W, Bornmann W, Marszalek JR, DePinho RA, Muller FL. Lin YH, et al. Among authors: ackroyd jj. Nat Metab. 2020 Dec;2(12):1413-1426. doi: 10.1038/s42255-020-00313-3. Epub 2020 Nov 23. Nat Metab. 2020. PMID: 33230295 Free PMC article.
Impaired anaplerosis is a major contributor to glycolysis inhibitor toxicity in glioma.
Khadka S, Arthur K, Barekatain Y, Behr E, Washington M, Ackroyd J, Crowley K, Suriyamongkol P, Lin YH, Pham CD, Zielinski R, Trujillo M, Galligan J, Georgiou DK, Asara J, Muller F. Khadka S, et al. Among authors: ackroyd j. Cancer Metab. 2021 Jun 25;9(1):27. doi: 10.1186/s40170-021-00259-4. Cancer Metab. 2021. PMID: 34172075 Free PMC article.
16 results