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Serial single-cell genomics reveals convergent subclonal evolution of resistance as early-stage breast cancer patients progress on endocrine plus CDK4/6 therapy.
Griffiths JI, Chen J, Cosgrove PA, O'Dea A, Sharma P, Ma C, Trivedi M, Kalinsky K, Wisinski KB, O'Regan R, Makhoul I, Spring LM, Bardia A, Adler FR, Cohen AL, Chang JT, Khan QJ, Bild AH. Griffiths JI, et al. Nat Cancer. 2021 Jun;2(6):658-671. doi: 10.1038/s43018-021-00215-7. Epub 2021 Jun 3. Nat Cancer. 2021. PMID: 34712959 Free PMC article.
Phylogenetic inference from single-cell RNA-seq data.
Liu X, Griffiths JI, Bishara I, Liu J, Bild AH, Chang JT. Liu X, et al. Among authors: griffiths ji. Sci Rep. 2023 Aug 8;13(1):12854. doi: 10.1038/s41598-023-39995-6. Sci Rep. 2023. PMID: 37553438 Free PMC article.
Biodiversity increases and decreases ecosystem stability.
Pennekamp F, Pontarp M, Tabi A, Altermatt F, Alther R, Choffat Y, Fronhofer EA, Ganesanandamoorthy P, Garnier A, Griffiths JI, Greene S, Horgan K, Massie TM, Mächler E, Palamara GM, Seymour M, Petchey OL. Pennekamp F, et al. Among authors: griffiths ji. Nature. 2018 Nov;563(7729):109-112. doi: 10.1038/s41586-018-0627-8. Epub 2018 Oct 17. Nature. 2018. PMID: 30333623
Opportunities for improving cancer treatment using systems biology.
Griffiths JI, Cohen AL, Jones V, Salgia R, Chang JT, Bild AH. Griffiths JI, et al. Curr Opin Syst Biol. 2019 Oct;17:41-50. doi: 10.1016/j.coisb.2019.10.018. Epub 2019 Nov 27. Curr Opin Syst Biol. 2019. PMID: 32518857 Free PMC article.
Individual differences determine the strength of ecological interactions.
Griffiths JI, Childs DZ, Bassar RD, Coulson T, Reznick DN, Rees M. Griffiths JI, et al. Proc Natl Acad Sci U S A. 2020 Jul 21;117(29):17068-17073. doi: 10.1073/pnas.2000635117. Epub 2020 Jul 6. Proc Natl Acad Sci U S A. 2020. PMID: 32631995 Free PMC article.
Phenotypic Consequences of SLC25A40-ABCB1 Fusions beyond Drug Resistance in High-Grade Serous Ovarian Cancer.
Pishas KI, Cowley KJ, Pandey A, Hoang T, Beach JA, Luu J, Vary R, Smith LK, Shembrey CE, Rashoo N, White MO, Simpson KJ, Bild A, Griffiths JI, Cheasley D, Campbell I, Bowtell DDL, Christie EL. Pishas KI, et al. Among authors: griffiths ji. Cancers (Basel). 2021 Nov 11;13(22):5644. doi: 10.3390/cancers13225644. Cancers (Basel). 2021. PMID: 34830797 Free PMC article.
Circulating immune cell phenotype dynamics reflect the strength of tumor-immune cell interactions in patients during immunotherapy.
Griffiths JI, Wallet P, Pflieger LT, Stenehjem D, Liu X, Cosgrove PA, Leggett NA, McQuerry JA, Shrestha G, Rossetti M, Sunga G, Moos PJ, Adler FR, Chang JT, Sharma S, Bild AH. Griffiths JI, et al. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16072-16082. doi: 10.1073/pnas.1918937117. Epub 2020 Jun 22. Proc Natl Acad Sci U S A. 2020. PMID: 32571915 Free PMC article.
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