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Page 1
Site-saturation mutagenesis by overlap extension PCR.
Williams EM, Copp JN, Ackerley DF. Williams EM, et al. Among authors: copp jn. Methods Mol Biol. 2014;1179:83-101. doi: 10.1007/978-1-4939-1053-3_6. Methods Mol Biol. 2014. PMID: 25055772
A conserved SH3-like fold in diverse putative proteins tetramerizes into an oxidoreductase providing an antimicrobial resistance phenotype.
Lemay-St-Denis C, Alejaldre L, Jemouai Z, Lafontaine K, St-Aubin M, Hitache K, Valikhani D, Weerasinghe NW, Létourneau M, Thibodeaux CJ, Doucet N, Baron C, Copp JN, Pelletier JN. Lemay-St-Denis C, et al. Among authors: copp jn. Philos Trans R Soc Lond B Biol Sci. 2023 Feb 27;378(1871):20220040. doi: 10.1098/rstb.2022.0040. Epub 2023 Jan 11. Philos Trans R Soc Lond B Biol Sci. 2023. PMID: 36633286 Free PMC article.
A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening.
Rich MH, Sharrock AV, Mulligan TS, Matthews F, Brown AS, Lee-Harwood HR, Williams EM, Copp JN, Little RF, Francis JJB, Horvat CN, Stevenson LJ, Owen JG, Saxena MT, Mumm JS, Ackerley DF. Rich MH, et al. Among authors: copp jn. Cell Chem Biol. 2023 Dec 21;30(12):1680-1691.e6. doi: 10.1016/j.chembiol.2023.10.001. Epub 2023 Oct 27. Cell Chem Biol. 2023. PMID: 37898120
A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening.
Rich MH, Sharrock AV, Mulligan TS, Matthews F, Brown AS, Lee-Harwood HR, Williams EM, Copp JN, Little RF, Francis JJ, Horvat CN, Stevenson LJ, Owen JG, Saxena MT, Mumm JS, Ackerley DF. Rich MH, et al. Among authors: copp jn. bioRxiv [Preprint]. 2023 Mar 25:2023.03.24.534183. doi: 10.1101/2023.03.24.534183. bioRxiv. 2023. PMID: 36993673 Free PMC article. Updated. Preprint.
Discovery of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases in Diverse Environmental Settings Suggests an Evolutionary Advantage Unrelated to Antibiotic Resistance.
Cellier-Goetghebeur S, Lafontaine K, Lemay-St-Denis C, Tsamo P, Bonneau-Burke A, Copp JN, Pelletier JN. Cellier-Goetghebeur S, et al. Among authors: copp jn. Antibiotics (Basel). 2022 Dec 7;11(12):1768. doi: 10.3390/antibiotics11121768. Antibiotics (Basel). 2022. PMID: 36551425 Free PMC article.
24 results