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Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach.
Betts A, Keunecke A, van Steeg TJ, van der Graaf PH, Avery LB, Jones H, Berkhout J. Betts A, et al. Among authors: berkhout j. MAbs. 2018 Jul;10(5):751-764. doi: 10.1080/19420862.2018.1462429. Epub 2018 May 14. MAbs. 2018. PMID: 29634430 Free PMC article.
Adaption to glucose limitation is modulated by the pleotropic regulator CcpA, independent of selection pressure strength.
Price CE, Branco Dos Santos F, Hesseling A, Uusitalo JJ, Bachmann H, Benavente V, Goel A, Berkhout J, Bruggeman FJ, Marrink SJ, Montalban-Lopez M, de Jong A, Kok J, Molenaar D, Poolman B, Teusink B, Kuipers OP. Price CE, et al. Among authors: berkhout j. BMC Evol Biol. 2019 Jan 10;19(1):15. doi: 10.1186/s12862-018-1331-x. BMC Evol Biol. 2019. PMID: 30630406 Free PMC article.
Understanding regulation of metabolism through feasibility analysis.
Nikerel E, Berkhout J, Hu F, Teusink B, Reinders MJ, de Ridder D. Nikerel E, et al. Among authors: berkhout j. PLoS One. 2012;7(7):e39396. doi: 10.1371/journal.pone.0039396. Epub 2012 Jul 9. PLoS One. 2012. PMID: 22808034 Free PMC article.