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Page 1
Structural basis for allosteric PARP-1 retention on DNA breaks.
Zandarashvili L, Langelier MF, Velagapudi UK, Hancock MA, Steffen JD, Billur R, Hannan ZM, Wicks AJ, Krastev DB, Pettitt SJ, Lord CJ, Talele TT, Pascal JM, Black BE. Zandarashvili L, et al. Among authors: steffen jd. Science. 2020 Apr 3;368(6486):eaax6367. doi: 10.1126/science.aax6367. Science. 2020. PMID: 32241924 Free PMC article.
PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain.
Dawicki-McKenna JM, Langelier MF, DeNizio JE, Riccio AA, Cao CD, Karch KR, McCauley M, Steffen JD, Black BE, Pascal JM. Dawicki-McKenna JM, et al. Among authors: steffen jd. Mol Cell. 2015 Dec 3;60(5):755-768. doi: 10.1016/j.molcel.2015.10.013. Epub 2015 Nov 25. Mol Cell. 2015. PMID: 26626480 Free PMC article.
Discovery and structure-activity relationship of novel 2,3-dihydrobenzofuran-7-carboxamide and 2,3-dihydrobenzofuran-3(2H)-one-7-carboxamide derivatives as poly(ADP-ribose)polymerase-1 inhibitors.
Patel MR, Bhatt A, Steffen JD, Chergui A, Murai J, Pommier Y, Pascal JM, Trombetta LD, Fronczek FR, Talele TT. Patel MR, et al. Among authors: steffen jd. J Med Chem. 2014 Jul 10;57(13):5579-601. doi: 10.1021/jm5002502. Epub 2014 Jun 25. J Med Chem. 2014. PMID: 24922587 Free PMC article.
14 results