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PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371.
Chen H, Bai Y, Kobayashi M, Xiao S, Cai W, Barajas S, Chen S, Miao J, Meke FN, Vemula S, Ropa JP, Croop JM, Boswell HS, Wan J, Jia Y, Liu H, Li LS, Altman JK, Eklund EA, Ji P, Tong W, Band H, Huang DT, Platanias LC, Zhang ZY, Liu Y. Chen H, et al. Among authors: ropa jp. Blood. 2023 Jan 19;141(3):244-259. doi: 10.1182/blood.2022016580. Blood. 2023. PMID: 36206490 Free PMC article.
Pharmacological inhibition of Carbonic Anhydrase IX and XII to enhance targeting of acute myeloid leukaemia cells under hypoxic conditions.
Chen F, Licarete E, Wu X, Petrusca D, Maguire C, Jacobsen M, Colter A, Sandusky GE, Czader M, Capitano ML, Ropa JP, Boswell HS, Carta F, Supuran CT, Parkin B, Fishel ML, Konig H. Chen F, et al. Among authors: ropa jp. J Cell Mol Med. 2021 Dec;25(24):11039-11052. doi: 10.1111/jcmm.17027. Epub 2021 Nov 17. J Cell Mol Med. 2021. PMID: 34791807 Free PMC article.