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Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells.
Khatri B, Tessneer KL, Rasmussen A, Aghakhanian F, Reksten TR, Adler A, Alevizos I, Anaya JM, Aqrawi LA, Baecklund E, Brun JG, Bucher SM, Eloranta ML, Engelke F, Forsblad-d'Elia H, Glenn SB, Hammenfors D, Imgenberg-Kreuz J, Jensen JL, Johnsen SJA, Jonsson MV, Kvarnström M, Kelly JA, Li H, Mandl T, Martín J, Nocturne G, Norheim KB, Palm Ø, Skarstein K, Stolarczyk AM, Taylor KE, Teruel M, Theander E, Venuturupalli S, Wallace DJ, Grundahl KM, Hefner KS, Radfar L, Lewis DM, Stone DU, Kaufman CE, Brennan MT, Guthridge JM, James JA, Scofield RH, Gaffney PM, Criswell LA, Jonsson R, Eriksson P, Bowman SJ, Omdal R, Rönnblom L, Warner B, Rischmueller M, Witte T, Farris AD, Mariette X, Alarcon-Riquelme ME; PRECISESADS Clinical Consortium; Shiboski CH; Sjögren’s International Collaborative Clinical Alliance (SICCA); Wahren-Herlenius M, Ng WF; UK Primary Sjögren’s Syndrome Registry; Sivils KL, Adrianto I, Nordmark G, Lessard CJ. Khatri B, et al. Nat Commun. 2022 Jul 27;13(1):4287. doi: 10.1038/s41467-022-30773-y. Nat Commun. 2022. PMID: 35896530 Free PMC article.
Vitamin d deficiency in a multiethnic healthy control cohort and altered immune response in vitamin D deficient European-American healthy controls.
Ritterhouse LL, Lu R, Shah HB, Robertson JM, Fife DA, Maecker HT, Du H, Fathman CG, Chakravarty EF, Scofield RH, Kamen DL, Guthridge JM, James JA. Ritterhouse LL, et al. PLoS One. 2014 Apr 11;9(4):e94500. doi: 10.1371/journal.pone.0094500. eCollection 2014. PLoS One. 2014. PMID: 24727903 Free PMC article.
Although there is extensive amount of research on vitamin D, we lack a comprehensive understanding of the prevalence of vitamin D deficiency or the mechanism by which vitamin D regulates the human immune system. This study examined the prevalence and correlat …
Although there is extensive amount of research on vitamin D, we lack a comprehensive understanding of the prevalence of vitamin D …
Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus.
Ritterhouse LL, Crowe SR, Niewold TB, Kamen DL, Macwana SR, Roberts VC, Dedeke AB, Harley JB, Scofield RH, Guthridge JM, James JA. Ritterhouse LL, et al. Ann Rheum Dis. 2011 Sep;70(9):1569-74. doi: 10.1136/ard.2010.148494. Epub 2011 May 17. Ann Rheum Dis. 2011. PMID: 21586442 Free PMC article.
METHODS: Serum samples from 32 European American female patients with SLE and 32 matched controls were tested for 25-hydroxyvitamin D (25(OH)D) levels, lupus-associated autoantibodies and serum IFNalpha activity. ...Patients with vitamin D deficiency also had …
METHODS: Serum samples from 32 European American female patients with SLE and 32 matched controls were tested for 25-hydroxyvitamin D …
Ataxia telangiectasia mutated kinase deficiency impairs the autophagic response early during myocardial infarction.
Thrasher PR, Scofield SLC, Dalal S, Crawford CC, Singh M, Singh K. Thrasher PR, et al. Am J Physiol Heart Circ Physiol. 2018 Jul 1;315(1):H48-H57. doi: 10.1152/ajpheart.00042.2018. Epub 2018 Apr 13. Am J Physiol Heart Circ Physiol. 2018. PMID: 29652546 Free PMC article.
ATM deficiency resulted in autophagic impairment during MI, as evidenced by decreased microtubule-associated protein light chain 3-II increased p62, decreased cathepsin D protein levels, and increased aggresome accumulation. ERK1/2 activation was only observed in WT-MI hea …
ATM deficiency resulted in autophagic impairment during MI, as evidenced by decreased microtubule-associated protein light chain 3-II increa …
Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B'-derived PPPGMRPP and PPPGIRGP induce spliceosome autoimmunity.
James JA, Gross T, Scofield RH, Harley JB. James JA, et al. J Exp Med. 1995 Feb 1;181(2):453-61. doi: 10.1084/jem.181.2.453. J Exp Med. 1995. PMID: 7530756 Free PMC article.
Eventually, the rabbits immunized with one octapeptide develop autoantibodies that bind other spliceosomal proteins including D, 70K, A, and C. Any mechanisms that operate to maintain tolerance or anergy for the spliceosome are thus overcome. ...
Eventually, the rabbits immunized with one octapeptide develop autoantibodies that bind other spliceosomal proteins including D, 70K, …