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Effect of acetazolamide on visual function in patients with idiopathic intracranial hypertension and mild visual loss: the idiopathic intracranial hypertension treatment trial.
NORDIC Idiopathic Intracranial Hypertension Study Group Writing Committee; Wall M, McDermott MP, Kieburtz KD, Corbett JJ, Feldon SE, Friedman DI, Katz DM, Keltner JL, Schron EB, Kupersmith MJ. NORDIC Idiopathic Intracranial Hypertension Study Group Writing Committee, et al. JAMA. 2014 Apr 23-30;311(16):1641-51. doi: 10.1001/jama.2014.3312. JAMA. 2014. PMID: 24756514 Free PMC article. Clinical Trial.
RESULTS: The mean improvement in PMD was greater with acetazolamide (1.43 dB, from -3.53 dB at baseline to -2.10 dB at month 6; n = 86) than with placebo (0.71 dB, from -3.53 dB to -2.82 dB; n = 79); the difference was 0.71 dB (95% CI, 0 to 1.43 dB; P = .050). Mean improve …
RESULTS: The mean improvement in PMD was greater with acetazolamide (1.43 dB, from -3.53 dB at baseline to -2.10 dB at month 6; n = 86) than …
Staphylococcus Great Britain and Ireland 2023 (StaphGBI 2023) Conference Report.
O'Gara JP, Zeden MS. O'Gara JP, et al. Access Microbiol. 2023 Dec 5;5(12):000730.v3. doi: 10.1099/acmi.0.000730.v3. eCollection 2023. Access Microbiol. 2023. PMID: 38188237 Free PMC article.
The 12th StaphGBI conference, hosted by University of Galway 22-23 June 2023, was co-chaired by Dr Merve S. Zeden and Professor James P. O'Gara, supported by a local organizing committee of Chloe Hobbs-Tobin, Dr Rakesh Roy, Orla Burke and Aaron Nolan. …
The 12th StaphGBI conference, hosted by University of Galway 22-23 June 2023, was co-chaired by Dr Merve S. Zeden and Professor James …
The impact of perioperative stroke and delirium on outcomes after surgical aortic valve replacement.
Messé SR, Overbey JR, Thourani VH, Moskowitz AJ, Gelijns AC, Groh MA, Mack MJ, Ailawadi G, Furie KL, Southerland AM, James ML, Moy CS, Gupta L, Voisine P, Perrault LP, Bowdish ME, Gillinov AM, O'Gara PT, Ouzounian M, Whitson BA, Mullen JC, Miller MA, Gammie JS, Pan S, Erus G, Browndyke JN; Cardiothoracic Surgical Trials Network (CTSN) Investigators. Messé SR, et al. J Thorac Cardiovasc Surg. 2024 Feb;167(2):624-633.e4. doi: 10.1016/j.jtcvs.2022.01.053. Epub 2022 Mar 18. J Thorac Cardiovasc Surg. 2024. PMID: 35483981 Clinical Trial.
At day 90, patients experiencing stroke were more likely to have a modified Rankin score >2 (odds ratio [OR], 5.9; 95% CI, 1.7-20.1; P = .01), depression (OR, 5.3; 95% CI, 1.6-17.3; P = .006), a lower 12-Item Short Form Survey physical health score (adjusted mean …
At day 90, patients experiencing stroke were more likely to have a modified Rankin score >2 (odds ratio [OR], 5.9; 95% CI, 1.7-20.1; P …
Pacemaker implantation associated with tricuspid repair in the setting of mitral valve surgery: Insights from a Cardiothoracic Surgical Trials Network randomized trial.
Ailawadi G, Voisine P, Raymond S, Gelijns AC, Moskowitz AJ, Falk V, Overbey JR, Chu MWA, Mack MJ, Bowdish ME, Krane M, Yerokun B, Conradi L, Bolling SF, Miller MA, Taddei-Peters WC, Fenton KN, Jeffries NO, Kramer RS, Geirsson A, Moquete EG, O'Sullivan K, Hupf J, Hung J, Beyersdorf F, Bagiella E, Gammie JS, O'Gara PT, Iribarne A, Borger MA, Gillinov M; trial investigators. Ailawadi G, et al. J Thorac Cardiovasc Surg. 2022 Dec 8:S0022-5223(22)01274-0. doi: 10.1016/j.jtcvs.2022.11.031. Online ahead of print. J Thorac Cardiovasc Surg. 2022. PMID: 36669972

Independent risk factors for PPM implantation within 2 years were TA (hazard ratio [HR], 5.94; 95% CI, 2.27-15.53; P < .001), increasing age (5 years, HR, 1.23; 95% CI, 1.01-1.52; P = .04), and left ventricular ejection fraction (LVEF; HR, 0.96; 95% CI, 0.92-0.99

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Independent risk factors for PPM implantation within 2 years were TA (hazard ratio [HR], 5.94; 95% CI, 2.27-15.53; P < .001), incr

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Infarct-related structural disconnection and delirium in surgical aortic valve replacement patients.
Browndyke JN, Tomalin LE, Erus G, Overbey JR, Kuceyeski A, Moskowitz AJ, Bagiella E, Iribarne A, Acker M, Mack M, Mathew J, O'Gara P, Gelijns AC, Suarez-Farinas M, Messé SR; Cardiothoracic Surgical Trials Network (CTSN) Investigators. Browndyke JN, et al. Ann Clin Transl Neurol. 2024 Feb;11(2):263-277. doi: 10.1002/acn3.51949. Epub 2023 Dec 28. Ann Clin Transl Neurol. 2024. PMID: 38155462 Free PMC article. Clinical Trial.

Delirium was associated with significantly increased lesion volumes in the right cerebellum and temporal lobe white matter, while diffusion weighted imaging infarct-related structural disconnection (DWI-ISD) was observed in frontal and temporal lobe regions (p-FDR < 0.0

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Delirium was associated with significantly increased lesion volumes in the right cerebellum and temporal lobe white matter, while diffusion …
The idiopathic intracranial hypertension treatment trial: clinical profile at baseline.
Wall M, Kupersmith MJ, Kieburtz KD, Corbett JJ, Feldon SE, Friedman DI, Katz DM, Keltner JL, Schron EB, McDermott MP; NORDIC Idiopathic Intracranial Hypertension Study Group. Wall M, et al. JAMA Neurol. 2014 Jun;71(6):693-701. doi: 10.1001/jamaneurol.2014.133. JAMA Neurol. 2014. PMID: 24756302 Free PMC article. Clinical Trial.
Lapses in Care Among Patients Assigned to Ranibizumab for Proliferative Diabetic Retinopathy: A Post Hoc Analysis of a Randomized Clinical Trial.
Maguire MG, Liu D, Bressler SB, Friedman SM, Melia M, Stockdale CR, Glassman AR, Sun JK; DRCR Retina Network. Maguire MG, et al. JAMA Ophthalmol. 2021 Dec 1;139(12):1266-1273. doi: 10.1001/jamaophthalmol.2021.4103. JAMA Ophthalmol. 2021. PMID: 34673898 Free PMC article. Clinical Trial.
Among the 120 participants who completed the 5-year examination, median change from baseline in visual acuity was -2 letters for participants who had 1 or more long lapse compared with +5 letters for those without a long lapse (P = .02). After multivariable adjustment, the …
Among the 120 participants who completed the 5-year examination, median change from baseline in visual acuity was -2 letters for participant …
Risk factors for poor visual outcome in patients with idiopathic intracranial hypertension.
Wall M, Falardeau J, Fletcher WA, Granadier RJ, Lam BL, Longmuir RA, Patel AD, Bruce BB, He H, McDermott MP; NORDIC Idiopathic Intracranial Hypertension Study Group. Wall M, et al. Neurology. 2015 Sep 1;85(9):799-805. doi: 10.1212/WNL.0000000000001896. Epub 2015 Aug 5. Neurology. 2015. PMID: 26245929 Free PMC article.
The odds ratio for patients with grades III to V papilledema vs those with grades I and II was 8.66 (95% confidence interval [CI] 1.65-, p = 0.025). A 1-unit decrease in the number of letters correct on the ETDRS (Early Treatment Diabetic Retinopathy Study) chart at baseli …
The odds ratio for patients with grades III to V papilledema vs those with grades I and II was 8.66 (95% confidence interval [CI] 1.65-, …