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Synthesis and pharmacological evaluation of newly detected synthetic cannabinoid receptor agonists AB-4CN-BUTICA, MMB-4CN-BUTINACA, MDMB-4F-BUTICA, MDMB-4F-BUTINACA and their analogs.
Sparkes E, Boyd R, Chen S, Markham JW, Luo JL, Foyzun T, Zaman H, Fletcher C, Ellison R, McGregor IS, Santiago MJ, Lai F, Gerona RR, Connor M, Hibbs DE, Cairns EA, Glass M, Ametovski A, Banister SD. Sparkes E, et al. Among authors: markham jw. Front Psychiatry. 2022 Sep 28;13:1010501. doi: 10.3389/fpsyt.2022.1010501. eCollection 2022. Front Psychiatry. 2022. PMID: 36245876 Free PMC article.
Defining Steric Requirements at CB1 and CB2 Cannabinoid Receptors Using Synthetic Cannabinoid Receptor Agonists 5F-AB-PINACA, 5F-ADB-PINACA, PX-1, PX-2, NNL-1, and Their Analogues.
Markham J, Sparkes E, Boyd R, Chen S, Manning JJ, Finlay D, Lai F, McGregor E, Maloney CJ, Gerona RR, Connor M, McGregor IS, Hibbs DE, Glass M, Kevin RC, Banister SD. Markham J, et al. ACS Chem Neurosci. 2022 Apr 20;13(8):1281-1295. doi: 10.1021/acschemneuro.2c00034. Epub 2022 Apr 11. ACS Chem Neurosci. 2022. PMID: 35404067
MEPIRAPIM-derived synthetic cannabinoids inhibit T-type calcium channels with divergent effects on seizures in rodent models of epilepsy.
Harman T, Udoh M, McElroy DL, Anderson LL, Kevin RC, Banister SD, Ametovski A, Markham J, Bladen C, Doohan PT, Greba Q, Laprairie RB, Snutch TP, McGregor IS, Howland JG, Arnold JC. Harman T, et al. Among authors: markham j. Front Physiol. 2023 Apr 4;14:1086243. doi: 10.3389/fphys.2023.1086243. eCollection 2023. Front Physiol. 2023. PMID: 37082241 Free PMC article.