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Page 1
ERS statement on respiratory muscle testing at rest and during exercise.
Laveneziana P, Albuquerque A, Aliverti A, Babb T, Barreiro E, Dres M, Dubé BP, Fauroux B, Gea J, Guenette JA, Hudson AL, Kabitz HJ, Laghi F, Langer D, Luo YM, Neder JA, O'Donnell D, Polkey MI, Rabinovich RA, Rossi A, Series F, Similowski T, Spengler CM, Vogiatzis I, Verges S. Laveneziana P, et al. Eur Respir J. 2019 Jun 13;53(6):1801214. doi: 10.1183/13993003.01214-2018. Print 2019 Jun. Eur Respir J. 2019. PMID: 30956204 Free article. Review.
cis-Dihydroxylated alpha-Trifluoromethylated N,O-Acetal from l-Tartaric Acid: Synthesis of Tetrasubstituted Stereocenter via Diastereoselective Pictet-Spengler Cyclization of N-Acyliminium Ions.
Ben Jamaa A, Latrache M, Riguet E, Grellepois F. Ben Jamaa A, et al. J Org Chem. 2020 Aug 7;85(15):9585-9598. doi: 10.1021/acs.joc.0c00801. Epub 2020 Jul 26. J Org Chem. 2020. PMID: 32790358
The synthesis of cyclic, chiral alpha-trifluoromethylated N,O-acetals having a protected cis-diol moiety has been readily achieved in two steps from a known bis-Weinreb amide derived from l-tartaric acid. The reaction of O-acetyl analogues of these N,O-acetal …
The synthesis of cyclic, chiral alpha-trifluoromethylated N,O-acetals having a protected cis-diol moiety has been readily achieved in …
GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis.
Zibrova D, Vandermoere F, Göransson O, Peggie M, Mariño KV, Knierim A, Spengler K, Weigert C, Viollet B, Morrice NA, Sakamoto K, Heller R. Zibrova D, et al. Biochem J. 2017 Mar 7;474(6):983-1001. doi: 10.1042/BCJ20160980. Biochem J. 2017. PMID: 28008135 Free article.
GFAT1 is the rate-limiting enzyme in the hexosamine biosynthesis pathway (HBP) and as such controls the modification of proteins by O-linked beta-N-acetylglucosamine (O-GlcNAc). In the present study, we tested the hypothesis that AMPK controls O-GlcNAc levels …
GFAT1 is the rate-limiting enzyme in the hexosamine biosynthesis pathway (HBP) and as such controls the modification of proteins by O …
Single step syntheses of (1S)-aryl-tetrahydroisoquinolines by norcoclaurine synthases.
Roddan R, Sula A, Méndez-Sánchez D, Subrizi F, Lichman BR, Broomfield J, Richter M, Andexer JN, Ward JM, Keep NH, Hailes HC. Roddan R, et al. Commun Chem. 2020 Nov 13;3(1):170. doi: 10.1038/s42004-020-00416-8. Commun Chem. 2020. PMID: 36703392 Free PMC article.
The enzyme norcoclaurine synthase (NCS), involved in plant alkaloid biosynthesis, has been shown to perform stereoselective Pictet-Spengler reactions between dopamine and several carbonyl substrates. ...A co-crystallised structure of the M97V variant with an active site re …
The enzyme norcoclaurine synthase (NCS), involved in plant alkaloid biosynthesis, has been shown to perform stereoselective Pictet-Spengl …
Retrospective cohort study to devise a treatment decision score predicting adverse 24-month radiological activity in early multiple sclerosis.
Hapfelmeier A, On BI, Mühlau M, Kirschke JS, Berthele A, Gasperi C, Mansmann U, Wuschek A, Bussas M, Boeker M, Bayas A, Senel M, Havla J, Kowarik MC, Kuhn K, Gatz I, Spengler H, Wiestler B, Grundl L, Sepp D, Hemmer B. Hapfelmeier A, et al. Ther Adv Neurol Disord. 2023 Mar 24;16:17562864231161892. doi: 10.1177/17562864231161892. eCollection 2023. Ther Adv Neurol Disord. 2023. PMID: 36993939 Free PMC article.
HIV-Associated Microbial Translocation May Affect Cytokine Production of CD56bright NK Cells via Stimulation of Monocytes.
ToVinh M, Hörr G, Hoffmeister C, Dobrikova K, Gotter C, Raabe J, Kaiser KM, Ahmad S, Finnemann C, Matejec E, Hack G, Bischoff J, Rieke GJ, Schwarze-Zander C, Boesecke C, van Bremen K, Wasmuth JC, Eis-Hübinger AM, Streeck H, Verhasselt HL, Oldenburg J, Strassburg CP, Rockstroh JK, Spengler U, Krämer B, Nattermann J. ToVinh M, et al. J Infect Dis. 2023 Feb 14;227(4):577-582. doi: 10.1093/infdis/jiac485. J Infect Dis. 2023. PMID: 36520641
A comparative study on the metal complexes of an anticancer estradiol-hydroxamate conjugate and salicylhydroxamic acid.
Mészáros JP, Kovács H, Spengler G, Kovács F, Frank É, Enyedy ÉA. Mészáros JP, et al. J Inorg Biochem. 2023 Jul;244:112223. doi: 10.1016/j.jinorgbio.2023.112223. Epub 2023 Apr 11. J Inorg Biochem. 2023. PMID: 37084580
Hydroxamic acids bearing an (O,O) donor set are well-known metal-chelating compounds with diverse biological activities including anticancer activity. ...
Hydroxamic acids bearing an (O,O) donor set are well-known metal-chelating compounds with diverse biological activities includ …
Iron(II)-cyclopentadienyl compounds are cytotoxic against colon adenocarcinoma cell lines: Ethylenebis(diphenylphosphane) vs. triphenylphosphane.
Pilon A, Avecilla F, Rácz B, Gátszegi GT, Spengler G, Robalo MP, Enyedy ÉA, Garcia MH, Valente A. Pilon A, et al. J Inorg Biochem. 2023 Dec;249:112386. doi: 10.1016/j.jinorgbio.2023.112386. Epub 2023 Sep 26. J Inorg Biochem. 2023. PMID: 37827090 Free article.
The presence of dppe in the compound's coordination sphere over (PPh(3) + CO) allows for more redox stable compounds showing higher cytotoxicity and selectivity, with improved cytotoxicity towards resistant cells that is not related to the inhibition of ABCB1. Further studies wit …
The presence of dppe in the compound's coordination sphere over (PPh(3) + CO) allows for more redox stable compounds showing higher cytotoxi …
Highly Antiproliferative Latonduine and Indolo[2,3-c]quinoline Derivatives: Complex Formation with Copper(II) Markedly Changes the Kinase Inhibitory Profile.
Wittmann C, Bacher F, Enyedy EA, Dömötör O, Spengler G, Madejski C, Reynisson J, Arion VB. Wittmann C, et al. J Med Chem. 2022 Feb 10;65(3):2238-2261. doi: 10.1021/acs.jmedchem.1c01740. Epub 2022 Feb 1. J Med Chem. 2022. PMID: 35104137 Free PMC article.
The structures of five compounds (HL(6), [CuCl(L(1))(DMF)].DMF, [CuCl(L(2))(CH(3)OH)], [CuCl(L(3))].0.5H(2)O, and [CuCl(2)(H(2)L(5))]Cl.2DMF) were elucidated by single crystal X-ray diffraction. ...
The structures of five compounds (HL(6), [CuCl(L(1))(DMF)].DMF, [CuCl(L(2))(CH(3)OH)], [CuCl(L(3))].0.5H(2)O, and [CuCl(2)(H(2)L(5))] …
65 results