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Therapeutic editing of hepatocyte genome in vivo.
Ruiz de Galarreta M, Lujambio A. Ruiz de Galarreta M, et al. J Hepatol. 2017 Oct;67(4):818-828. doi: 10.1016/j.jhep.2017.05.012. Epub 2017 May 17. J Hepatol. 2017. PMID: 28527665 Review.
Programmable nucleases, such as meganucleases, zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeat (CRISPR)-associated nucleases have revolutionized the way research is conduct …
Programmable nucleases, such as meganucleases, zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) …
Targeted DNA mutagenesis for the cure of chronic viral infections.
Schiffer JT, Aubert M, Weber ND, Mintzer E, Stone D, Jerome KR. Schiffer JT, et al. J Virol. 2012 Sep;86(17):8920-36. doi: 10.1128/JVI.00052-12. Epub 2012 Jun 20. J Virol. 2012. PMID: 22718830 Free PMC article. Review.
Human immunodeficiency virus type 1 (HIV-1), hepatitis B virus (HBV), and herpes simplex virus (HSV) have been incurable to date because effective antiviral therapies target only replicating viruses and do not eradicate latently integrated or nonreplicating episomal viral …
Human immunodeficiency virus type 1 (HIV-1), hepatitis B virus (HBV), and herpes simplex virus (HSV) have been incurable to date beca …
BMP-2 Genome-Edited Human MSCs Protect against Cartilage Degeneration via Suppression of IL-34 in Collagen-Induced Arthritis.
Chae DS, Han S, Lee MK, Kim SW. Chae DS, et al. Int J Mol Sci. 2023 May 4;24(9):8223. doi: 10.3390/ijms24098223. Int J Mol Sci. 2023. PMID: 37175932 Free PMC article.
The BMP-2 gene was synthesized and inserted into AMMs using transcription activator-like effector nucleases (TALENs), and BMP-2-overexpressing AMMs (AMM/B) were sorted and characterized using quantitative reverse transcription polymerase chain reaction (qRT-PCR). .. …
The BMP-2 gene was synthesized and inserted into AMMs using transcription activator-like effector nucleases (TALENs), and BMP-2-overe …
HDR-based CRISPR/Cas9-mediated Knockout of PD-L1 in C57BL/6 Mice.
Heeb LV, Taskoparan B, Katsoulas A, Beffinger M, Clavien PA, Kobold S, Gupta A, Berg JV. Heeb LV, et al. Bio Protoc. 2023 Jul 20;13(14):e4724. doi: 10.21769/BioProtoc.4724. eCollection 2023 Jul 20. Bio Protoc. 2023. PMID: 37497456 Free PMC article.
Similar to its predecessors, the Zinc finger nucleases or transcription activator-like effector nucleases (TALENs), CRISPR/Cas9 catalyzes double-strand DNA breaks, which can result in frameshift mutations due to random nucleotide insertions or deletions via non-homologous …
Similar to its predecessors, the Zinc finger nucleases or transcription activator-like effector nucleases (TALENs), CRISPR/Cas9 catal …
Association between coffee consumption and total dietary caffeine intake with cognitive functioning: cross-sectional assessment in an elderly Mediterranean population.
Paz-Graniel I, Babio N, Becerra-Tomás N, Toledo E, Camacho-Barcia L, Corella D, Castañer-Niño O, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Tinahones FJ, Fernandez-Aranda F, Lapetra J, Pintó X, Tur JA, García-Rios A, Bueno-Cavanillas A, Gaforio JJ, Matía-Martín P, Daimiel L, Sánchez VM, Vidal J, Prieto-Sanchez L, Ros E, Razquin C, Mestres C, Sorli JV, Cuenca-Royo AM, Rios A, Torres-Collado L, Vaquero-Luna J, Pérez-Farinós N, Zulet MA, Sanchez-Villegas A, Casas R, Bernal-Lopez MR, Santos-Lozano JM, Corbella X, Mateos D, Buil-Cosiales P, Jiménez-Murcia S, Fernandez-Carrion R, Forcano-Gamazo L, López M, Sempere-Pascual MÁ, Moreno-Rodriguez A, Gea A, de la Torre-Fornell R, Salas-Salvadó J; PREDIMED-Plus Investigators. Paz-Graniel I, et al. Eur J Nutr. 2021 Aug;60(5):2381-2396. doi: 10.1007/s00394-020-02415-w. Epub 2020 Oct 30. Eur J Nutr. 2021. PMID: 33125576
Results were similar when cognitive performance was measured using the Clock Drawing Test (CDT) and Trail Making Test B (TMT-B). These associations were not observed for decaffeinated coffee consumption. ...
Results were similar when cognitive performance was measured using the Clock Drawing Test (CDT) and Trail Making Test B (TMT-B …
Genoproteomics-assisted improvement of Andrographis paniculata: toward a promising molecular and conventional breeding platform for autogamous plants affecting the pharmaceutical industry.
Valdiani A, Talei D, Lattoo SK, Ortiz R, Rasmussen SK, Batley J, Rafii MY, Maziah M, Sabu KK, Abiri R, Sakuanrungsirikul S, Tan SG. Valdiani A, et al. Crit Rev Biotechnol. 2017 Sep;37(6):803-816. doi: 10.1080/07388551.2016.1260525. Epub 2017 Jan 3. Crit Rev Biotechnol. 2017. PMID: 28049346 Review.
Finally, this review suggests that novel site-directed genome editing approaches such as TALENs (Transcription Activator-Like Effector Nucleases) and CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated protein-9 nuclease) systems toge …
Finally, this review suggests that novel site-directed genome editing approaches such as TALENs (Transcription Activator-Like Effecto …
TALEN-Mediated Homologous Recombination Produces Site-Directed DNA Base Change and Herbicide-Resistant Rice.
Li T, Liu B, Chen CY, Yang B. Li T, et al. J Genet Genomics. 2016 May 20;43(5):297-305. doi: 10.1016/j.jgg.2016.03.005. Epub 2016 Mar 22. J Genet Genomics. 2016. PMID: 27180265
The breakthrough has been made in recent years with the advent of sequence-specific endonucleases, especially zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeats (CRISPRs) guid …
The breakthrough has been made in recent years with the advent of sequence-specific endonucleases, especially zinc finger nucleases (ZFNs), …
iPSC-Derived Microglia for Modeling Human-Specific DAMP and PAMP Responses in the Context of Alzheimer's Disease.
Ihnatovych I, Birkaya B, Notari E, Szigeti K. Ihnatovych I, et al. Int J Mol Sci. 2020 Dec 18;21(24):9668. doi: 10.3390/ijms21249668. Int J Mol Sci. 2020. PMID: 33352944 Free PMC article.
To provide the human context, isogenic induced pluripotent stem cell (iPSC) lines were developed from CHRFAM7A null and carrier individuals by genome-editing the null line using TALENs to knock-in CHRFAM7A. In iPSC-derived microglia-like cells, CHRFAM7A mitigated Abeta upt …
To provide the human context, isogenic induced pluripotent stem cell (iPSC) lines were developed from CHRFAM7A null and carrier individuals …
Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases.
Ménoret S, Fontanière S, Jantz D, Tesson L, Thinard R, Rémy S, Usal C, Ouisse LH, Fraichard A, Anegon I. Ménoret S, et al. FASEB J. 2013 Feb;27(2):703-11. doi: 10.1096/fj.12-219907. Epub 2012 Nov 12. FASEB J. 2013. PMID: 23150522
Despite the recent availability of gene-specific nucleases, such as zinc-finger nucleases (ZFNs) and transcription activator-like nucleases (TALENs), there is still a need for new tools to modify the genome of different species in an efficient, rapid, and less costly manne …
Despite the recent availability of gene-specific nucleases, such as zinc-finger nucleases (ZFNs) and transcription activator-like nucleases …
Apolipoprotein B100 is required for hepatitis C infectivity and Mipomersen inhibits hepatitis C.
Schaefer EA, Meixiong J, Mark C, Deik A, Motola DL, Fusco D, Yang A, Brisac C, Salloum S, Lin W, Clish CB, Peng LF, Chung RT. Schaefer EA, et al. World J Gastroenterol. 2016 Dec 7;22(45):9954-9965. doi: 10.3748/wjg.v22.i45.9954. World J Gastroenterol. 2016. PMID: 28018102 Free PMC article.
METHODS: In this study, we utilize a gene editing tool, transcription activator-like effector nucleases (TALENs), to generate human hepatoma cells with a stable genetic deletion of APOB to assess of apoB in HCV. ...
METHODS: In this study, we utilize a gene editing tool, transcription activator-like effector nucleases (TALENs), to generate human h …
14 results