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Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies.
Nunes IKDC, de Souza ET, Martins IRR, Barbosa G, Moraes Junior MO, Medeiros MM, Silva SWD, Balliano TL, da Silva BA, Silva PMR, Carvalho VF, Martins MA, Lima LM. Nunes IKDC, et al. Eur J Med Chem. 2020 Oct 15;204:112492. doi: 10.1016/j.ejmech.2020.112492. Epub 2020 Jul 18. Eur J Med Chem. 2020. PMID: 32717478
Ent-7α-acetoxytrachyloban-18-oic acid and ent-7α-hydroxytrachyloban-18-oic acid from Xylopia langsdorfiana A. St-Hil. & Tul. modulate K(+) and Ca(2+) channels to reduce cytosolic calcium concentration on guinea pig ileum.
Santos RF, Martins IR, Travassos RA, Tavares JF, Silva MS, Paredes-Gamero EJ, Ferreira AT, Nouailhetas VL, Aboulafia J, Rigoni VL, da Silva BA. Santos RF, et al. Among authors: martins ir. Eur J Pharmacol. 2012 Mar 5;678(1-3):39-47. doi: 10.1016/j.ejphar.2011.12.028. Epub 2011 Dec 27. Eur J Pharmacol. 2012. PMID: 22214536 Free article.
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