Study of the Inhibitory Effects of Enteral Nutrition Formula on Indomethacin-Induced Gastric Lesions in Mice

Nutrients. 2019 Dec 14;11(12):3058. doi: 10.3390/nu11123058.

Abstract

We investigated the effects of enteral nutrition formula on non-steroidal anti-inflammatory drug (NSAID)-induced gastric lesions in mice. Male ICR mice aged 7-9 weeks old were fasted, then orally given either purified water, Mermed® One, or 2-fold diluted Terumeal® 2.0α as enteral nutrition (25 or 50 mL/kg each). Indomethacin (IND) was orally administered at 20 mg/kg after 30 min, and the stomach was removed 6 h later and fixed in formalin. The number and area of lesions in the stomachs of the mice given enteral nutrition showed a significant, dose-dependent decrease compared to the purified water-treated group, and no significant difference was seen between the two enteral nutrition-treated groups. Comparable time courses of plasma IND concentrations suggest that enteral nutrition does not inhibit gastrointestinal absorption of IND. Our findings indicate that administering enteral nutrition could inhibit the onset of NSAID-induced gastric ulcers.

Keywords: enteral nutrition formula; gastric lesions; non-steroidal anti-inflammatory drugs.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / toxicity
  • Enteral Nutrition*
  • Food, Formulated*
  • Gastric Mucosa / drug effects
  • Gastric Mucosa / pathology
  • Humans
  • Indomethacin / toxicity*
  • Male
  • Mice
  • Mice, Inbred ICR
  • Stomach Ulcer / chemically induced*
  • Stomach Ulcer / drug therapy*
  • Stomach Ulcer / pathology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Indomethacin