Abstract
Four new p-aminoacetophenonic acids, named (2E)-11-(4'-aminophenyl)-5,9-dihydroxy-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (1), 9-(4'-aminophenyl)-3,7-dihydroxy-2,4,6-trimethyl-9-oxo-nonoic acid(2), (2E)-11-(4'-aminophenyl)-5,9-O-cyclo-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (3) and 9-(4'-aminophenyl)-3,7-O-cyclo-2,4,6-trimethyl-9-oxo-nonoic acid(4), were isolated from an endophyte Streptomyces sp. (strain HK10552) of the mangrove plant Aegiceras corniculatum. The structures of 1-4 were elucidated by using spectroscopic analyses. The relative stereoconfigurations of compounds 3 and 4 were determined by NOESY experiments. In the bioassay test, 1-4 showed no cytotoxicity against the Hela cell lines. Compound 4 also showed no inhibitory bioactivity on HCV protease and SecA ATPase and wasn't active against VSVG/HIV-luc pseudotyping virus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetophenones / chemistry*
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Acetophenones / isolation & purification
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Acetophenones / pharmacology
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Adenosine Triphosphatases / antagonists & inhibitors
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Antiviral Agents / chemistry*
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Antiviral Agents / isolation & purification
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Antiviral Agents / pharmacology
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Bacterial Proteins / antagonists & inhibitors
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HeLa Cells
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Hepacivirus / enzymology
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Humans
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Membrane Transport Proteins
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Primulaceae / microbiology*
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Protease Inhibitors / chemistry*
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Protease Inhibitors / isolation & purification
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Protease Inhibitors / pharmacology
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SEC Translocation Channels
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SecA Proteins
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Streptomyces / chemistry*
Substances
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Acetophenones
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Antineoplastic Agents
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Antiviral Agents
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Bacterial Proteins
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Membrane Transport Proteins
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Protease Inhibitors
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SEC Translocation Channels
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Adenosine Triphosphatases
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SecA Proteins