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Year Number of Results
2016 2
2018 2
2019 1
2020 2
2022 4
2024 0

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11 results

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Page 1
Design, synthesis, and biological evaluation of new thalidomide-donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation.
Cristancho Ortiz CJ, de Freitas Silva M, Pruccoli L, Fonseca Nadur N, de Azevedo LL, Kümmerle AE, Guedes IA, Dardenne LE, Leomil Coelho LF, Guimarães MJ, da Silva FMR, Castro N, Gontijo VS, Rojas VCT, de Oliveira MK, Vilela FC, Giusti-Paiva A, Barbosa G, Lima LM, Pinheiro GB, Veras LG, Mortari MR, Tarozzi A, Viegas C Jr. Cristancho Ortiz CJ, et al. Among authors: guedes ia. RSC Med Chem. 2022 Mar 17;13(5):568-584. doi: 10.1039/d1md00374g. eCollection 2022 May 25. RSC Med Chem. 2022. PMID: 35694691 Free PMC article.
Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer's disease.
Macedo Vaz S, de Freitas Silva M, Dos Reis Rosa Franco G, Jorge R Guimarães M, Motta R da Silva F, Gonçalves Castro N, Alvim Guedes I, Dardenne LE, Amaral Alves M, Garrett da Costa R, Beserra Pinheiro G, Germino Veras L, Renata Mortari M, Pruccoli L, Tarozzi A, Viegas C Jr. Macedo Vaz S, et al. Among authors: alvim guedes i. Bioorg Med Chem. 2022 Oct 1;71:116952. doi: 10.1016/j.bmc.2022.116952. Epub 2022 Aug 1. Bioorg Med Chem. 2022. PMID: 35930852
Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer's Disease.
de Freitas Silva M, Tardelli Lima E, Pruccoli L, Castro NG, Guimarães MJR, M R da Silva F, Fonseca Nadur N, de Azevedo LL, Kümmerle AE, Guedes IA, Dardenne LE, Gontijo VS, Tarozzi A, Viegas C. de Freitas Silva M, et al. Among authors: guedes ia. Molecules. 2020 Jul 10;25(14):3165. doi: 10.3390/molecules25143165. Molecules. 2020. PMID: 32664425 Free PMC article.
Anti-Restriction Gene Homologs Are Highly Represented in Methicillin-Resistant and Multidrug-Resistant Staphylococcus aureus ST239 and ST398: Implications for Resistance Gene Acquisitions.
Silva DNS, Beltrame CO, Botelho AMN, Martini CL, Esteves MAC, Guedes IA, Dardenne LE, Figueiredo AMS. Silva DNS, et al. Among authors: guedes ia. Antibiotics (Basel). 2022 Sep 8;11(9):1217. doi: 10.3390/antibiotics11091217. Antibiotics (Basel). 2022. PMID: 36139996 Free PMC article.
Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates.
Dias Viegas FP, de Freitas Silva M, Divino da Rocha M, Castelli MR, Riquiel MM, Machado RP, Vaz SM, Simões de Lima LM, Mancini KC, Marques de Oliveira PC, Morais ÉP, Gontijo VS, da Silva FMR, D'Alincourt da Fonseca Peçanha D, Castro NG, Neves GA, Giusti-Paiva A, Vilela FC, Orlandi L, Camps I, Veloso MP, Leomil Coelho LF, Ionta M, Ferreira-Silva GÁ, Pereira RM, Dardenne LE, Guedes IA, de Oliveira Carneiro Junior W, Quaglio Bellozi PM, Pinheiro de Oliveira AC, Ferreira FF, Pruccoli L, Tarozzi A, Viegas C Jr. Dias Viegas FP, et al. Among authors: guedes ia. Eur J Med Chem. 2018 Mar 10;147:48-65. doi: 10.1016/j.ejmech.2018.01.066. Epub 2018 Jan 31. Eur J Med Chem. 2018. PMID: 29421570
Design, synthesis, cholinesterase inhibition and molecular modelling study of novel tacrine hybrids with carbohydrate derivatives.
Lopes JPB, Silva L, da Costa Franarin G, Antonio Ceschi M, Seibert Lüdtke D, Ferreira Dantas R, de Salles CMC, Paes Silva-Jr F, Roberto Senger M, Alvim Guedes I, Emmanuel Dardenne L. Lopes JPB, et al. Among authors: alvim guedes i. Bioorg Med Chem. 2018 Nov 1;26(20):5566-5577. doi: 10.1016/j.bmc.2018.10.003. Epub 2018 Oct 9. Bioorg Med Chem. 2018. PMID: 30340901
Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling.
Lopes JPB, Silva L, Ceschi MA, Lüdtke DS, Zimmer AR, Ruaro TC, Dantas RF, de Salles CMC, Silva-Jr FP, Senger MR, Barbosa G, Lima LM, Guedes IA, Dardenne LE. Lopes JPB, et al. Among authors: guedes ia. Medchemcomm. 2019 Nov 8;10(12):2089-2101. doi: 10.1039/c9md00358d. eCollection 2019 Dec 1. Medchemcomm. 2019. PMID: 32904099 Free PMC article.
A unique SaeS allele overrides cell-density dependent expression of saeR and lukSF-PV in the ST30-SCCmecIV lineage of CA-MRSA.
Ramundo MS, Beltrame CO, Botelho AM, Coelho LR, Silva-Carvalho MC, Ferreira-Carvalho BT, Nicolás MF, Guedes IA, Dardenne LE, O'Gara J, Figueiredo AM. Ramundo MS, et al. Among authors: guedes ia. Int J Med Microbiol. 2016 Sep;306(6):367-80. doi: 10.1016/j.ijmm.2016.05.001. Epub 2016 May 11. Int J Med Microbiol. 2016. PMID: 27265234
11 results