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Page 1
P66Shc signals to age.
Trinei M, Berniakovich I, Beltrami E, Migliaccio E, Fassina A, Pelicci P, Giorgio M. Trinei M, et al. Among authors: berniakovich i. Aging (Albany NY). 2009 Jun 5;1(6):503-10. doi: 10.18632/aging.100057. Aging (Albany NY). 2009. PMID: 20157533 Free PMC article. Review.
p66Shc-generated oxidative signal promotes fat accumulation.
Berniakovich I, Trinei M, Stendardo M, Migliaccio E, Minucci S, Bernardi P, Pelicci PG, Giorgio M. Berniakovich I, et al. J Biol Chem. 2008 Dec 5;283(49):34283-93. doi: 10.1074/jbc.M804362200. Epub 2008 Oct 6. J Biol Chem. 2008. PMID: 18838380 Free PMC article.
The Shc locus regulates insulin signaling and adiposity in mammals.
Tomilov AA, Ramsey JJ, Hagopian K, Giorgio M, Kim KM, Lam A, Migliaccio E, Lloyd KC, Berniakovich I, Prolla TA, Pelicci P, Cortopassi GA. Tomilov AA, et al. Among authors: berniakovich i. Aging Cell. 2011 Feb;10(1):55-65. doi: 10.1111/j.1474-9726.2010.00641.x. Epub 2010 Nov 15. Aging Cell. 2011. PMID: 21040401 Free PMC article.
The p66Shc knocked out mice are short lived under natural condition.
Giorgio M, Berry A, Berniakovich I, Poletaeva I, Trinei M, Stendardo M, Hagopian K, Ramsey JJ, Cortopassi G, Migliaccio E, Nötzli S, Amrein I, Lipp HP, Cirulli F, Pelicci PG. Giorgio M, et al. Among authors: berniakovich i. Aging Cell. 2012 Feb;11(1):162-8. doi: 10.1111/j.1474-9726.2011.00770.x. Epub 2011 Dec 28. Aging Cell. 2012. PMID: 22081964 Free article.
Neuronopathic Gaucher's disease: induced pluripotent stem cells for disease modelling and testing chaperone activity of small compounds.
Tiscornia G, Vivas EL, Matalonga L, Berniakovich I, Barragán Monasterio M, Eguizábal C, Gort L, González F, Ortiz Mellet C, García Fernández JM, Ribes A, Veiga A, Izpisua Belmonte JC. Tiscornia G, et al. Among authors: berniakovich i. Hum Mol Genet. 2013 Feb 15;22(4):633-45. doi: 10.1093/hmg/dds471. Epub 2012 Oct 31. Hum Mol Genet. 2013. PMID: 23118351