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Stapled ACE2 peptidomimetics designed to target the SARS-CoV-2 spike protein do not prevent virus internalization.
Morgan DC, Morris C, Mahindra A, Blair CM, Tejeda G, Herbert I, Turnbull ML, Lieber G, Willett BJ, Logan N, Smith B, Tobin AB, Bhella D, Baillie G, Jamieson AG. Morgan DC, et al. Among authors: herbert i. Pept Sci (Hoboken). 2021 Jul;113(4):e24217. doi: 10.1002/pep2.24217. Epub 2021 Jan 8. Pept Sci (Hoboken). 2021. PMID: 33615115 Free PMC article.
Severe Acute Respiratory Syndrome Coronavirus 2 Serosurveillance in a Patient Population Reveals Differences in Virus Exposure and Antibody-Mediated Immunity According to Host Demography and Healthcare Setting.
Hughes EC, Amat JAR, Haney J, Parr YA, Logan N, Palmateer N, Nickbakhsh S, Ho A, Cherepanov P, Rosa A, McAuley A, Broos A, Herbert I, Arthur U, Szemiel AM, Roustan C, Dickson E, Gunson RN, Viana M, Willett BJ, Murcia PR. Hughes EC, et al. Among authors: herbert i. J Infect Dis. 2021 Mar 29;223(6):971-980. doi: 10.1093/infdis/jiaa788. J Infect Dis. 2021. PMID: 33367847 Free PMC article.
Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction.
Mahindra A, Tejeda G, Rossi M, Janha O, Herbert I, Morris C, Morgan DC, Beattie W, Montezano AC, Hudson B, Tobin AB, Bhella D, Touyz RM, Jamieson AG, Baillie GS, Blair CM. Mahindra A, et al. Among authors: herbert i. PLoS One. 2021 Nov 18;16(11):e0260283. doi: 10.1371/journal.pone.0260283. eCollection 2021. PLoS One. 2021. PMID: 34793553 Free PMC article.